4-(Trifluoromethyl)furan-2(5H)-one

Base Information

Chemical Name:4-(Trifluoromethyl)furan-2(5H)-one
CAS No.:102854-63-7
Molecular Formula:C₅H₃F₃O₂
Molecular Weight:152.073
Hs Code.:
DSSTox Substance ID:DTXSID60542299
Wikidata:Q82418913
Mol file:102854-63-7.mol

Synonyms:4-(Trifluoromethyl)furan-2(5H)-one;102854-63-7;3-(trifluoromethyl)-2H-furan-5-one;4-(trifluoromethyl)-2,5-dihydrofuran-2-one;MFCD23381704;4-Trifluoromethyl-5H-furan-2-one;2(5H)-Furanone, 4-(trifluoromethyl)-;DTXSID60542299;LZEDCESLESUNKB-UHFFFAOYSA-N;4-Trifluoromethyl-2(5H)-furanone;CEA85463;AC2742;AKOS017344741;AS-62644;SY237799;EN300-207014

Suppliers and Price of 4-(Trifluoromethyl)furan-2(5H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-(Trifluoromethyl)furan-2(5H)-one

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:152.00851382
Heavy Atom Count:10
Complexity:192

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=CC(=O)O1)C(F)(F)F

Technology Process of 4-(Trifluoromethyl)furan-2(5H)-one

There total 1 articles about 4-(Trifluoromethyl)furan-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69877-86-7
ethyl (Z)-3-(bromomethyl)-4,4,4-trifluoro-but-2-enoate

: 102854-63-7
4-trifluoromethyl-2-(5H)-furanone

Guidance literature:: With hydrogenchloride; silver trifluoroacetate; Yield given. Multistep reaction; 1.) acetonitrile, 6 h, r.t; 2.) methanol, 16 h, r.t.;
DOI:10.1248/cpb.33.4026

Reference yield:

: 102854-63-7
4-trifluoromethyl-2-(5H)-furanone

: 102854-66-0
3-(Methoxy-phenyl-methyl)-4-trifluoromethyl-5H-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / triethylamine / zinc chloride / diethyl ether / 2 h / 0 °C

2: BF₃Et₂O / diethyl ether / 2 h / Ambient temperature

With triethylamine; boron trifluoride diethyl etherate; zinc(II) chloride; In diethyl ether;

Reference yield:

: 102854-63-7
4-trifluoromethyl-2-(5H)-furanone

: (S)-4,4,4-Trifluoro-3-phenylsulfanylmethyl-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / H₂ / 5percent Pd-C / methanol

2: toluene / 6 h / Heating

3: Et₃N / CH₂Cl₂ / 0 °C

4: NaH / tetrahydrofuran / Ambient temperature

5: c-HCl / acetic acid / 13 h / Heating

With hydrogenchloride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; toluene;
DOI:10.1016/S0040-4039(00)85148-5