ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate

Base Information

Chemical Name:ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate
CAS No.:39683-24-4
Molecular Formula:C12H12N2O3
Molecular Weight:232.239
Hs Code.:2933199090
European Community (EC) Number:827-341-5
NSC Number:44688
DSSTox Substance ID:DTXSID90286311
Wikidata:Q82022003
ChEMBL ID:CHEMBL1414389
Mol file:39683-24-4.mol

Synonyms:ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate;39683-24-4;ethyl 4-hydroxy-1-phenylpyrazole-3-carboxylate;MLS000736593;NSC44688;CBMicro_045787;Oprea1_705878;CHEMBL1414389;DTXSID90286311;HMS2885C21;NSC-44688;STL228305;AKOS001045062;SMR000528210;BIM-0045919.P001;CS-0220511;EN300-06852;ethyl4-hydroxy-1-phenyl-pyrazole-3-carboxylate;AB00690658-02;ethyl4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate;SR-01000219319;SR-01000219319-1;Z56947545;F0307-0409

Suppliers and Price of ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL 4-HYDROXY-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE 95.00%
1G
$ 794.34

Abosyn
ethyl4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate 95%-98%
1g
$ 650.00

Total 9 raw suppliers

Chemical Property of ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate

Chemical Property:

Vapor Pressure:1.5E-05mmHg at 25°C
Boiling Point:355.7°C at 760 mmHg
Flash Point:168.9°C
PSA：64.35000
Density:1.25g/cm³
LogP:1.75460
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:232.08479225
Heavy Atom Count:17
Complexity:267

Purity/Quality:

97% ^*data from raw suppliers

ETHYL 4-HYDROXY-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=NN(C=C1O)C2=CC=CC=C2

Technology Process of ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate

There total 8 articles about ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 252367-34-3
ethyl 4-chloro-2-(phenylhydrazono)-3-oxobutanoate

: 39683-24-4
ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate

Guidance literature:: With potassium acetate; In ethanol; at 100 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1016/j.bmc.2020.115610

Reference yield:

: 39683-28-8
4-bromo-3-oxo-2-phenylhydrazono-butyric acid ethyl ester

: 39683-24-4
ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate

Guidance literature:: With ethanol; potassium acetate;

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 62-53-3
aniline

: 39683-24-4
ethyl 4-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; sodium nitrite; sulfuric acid / 1 h / 10 °C

1.2: 1.25 h / 0 - 10 °C

1.3: 0 - 20 °C

2.1: potassium acetate / ethanol / 100 °C / Schlenk technique; Inert atmosphere

With sulfuric acid; potassium acetate; acetic acid; sodium nitrite; In ethanol;
DOI:10.1016/j.bmc.2020.115610