5-Pyrimidinecarboxylic acid, 4-[2-[(4-chlorophenyl)thio]phenyl]-6-methyl-2-phenyl-, ethyl ester

Base Information

• Chemical Name: 5-Pyrimidinecarboxylic acid, 4-[2-[(4-chlorophenyl)thio]phenyl]-6-methyl-2-phenyl-, ethyl ester
• CAS No.: 103293-67-0
• Molecular Formula: C26H21ClN2O2S
• Molecular Weight: 460.984
• Mol file: 103293-67-0.mol

Synonyms:

Chemical Property of 5-Pyrimidinecarboxylic acid, 4-[2-[(4-chlorophenyl)thio]phenyl]-6-methyl-2-phenyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 4-[2-[(4-chlorophenyl)thio]phenyl]-6-methyl-2-phenyl-, ethyl ester

There total 6 articles about 5-Pyrimidinecarboxylic acid, 4-[2-[(4-chlorophenyl)thio]phenyl]-6-methyl-2-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.7%

4-[2-(4-Chloro-phenylsulfanyl)-phenyl]-6-methyl-2-phenyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester (143996-71-8) → ethyl 4-[2-(4-chlorophenylthio)phenyl]-6-methyl-2-phenyl-5-pyrimidinecarboxylate (103293-67-0)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 2h; Heating;

DOI:10.1248/cpb.40.1452

Reference yield:

benzamidine monohydrochloride (1670-14-0) → ethyl 4-[2-(4-chlorophenylthio)phenyl]-6-methyl-2-phenyl-5-pyrimidinecarboxylate (103293-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 50.1 percent / Et₃N / butan-1-ol / 1.5 h / Heating

2: 68.7 percent / MnO₂ / CHCl₃ / 2 h / Heating

With manganese(IV) oxide; triethylamine; In chloroform; butan-1-ol;

DOI:10.1248/cpb.40.1452

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl 4-[2-(4-chlorophenylthio)phenyl]-6-methyl-2-phenyl-5-pyrimidinecarboxylate (103293-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine, AcOH / benzene / 1 h / Heating

2: 50.1 percent / Et₃N / butan-1-ol / 1.5 h / Heating

3: 68.7 percent / MnO₂ / CHCl₃ / 2 h / Heating

With piperidine; manganese(IV) oxide; acetic acid; triethylamine; In chloroform; butan-1-ol; benzene;

DOI:10.1248/cpb.40.1452

upstream raw materials:

4-[2-(4-Chloro-phenylsulfanyl)-phenyl]-6-methyl-2-phenyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

benzamidine monohydrochloride

ethyl acetoacetate

2-[(4-chlorophenyl)thio]benzaldehyde

Refernces

• 1、 -. "Pyrimidine derivatives, processes for preparation thereof and composition containing the same". . . Retrieved 2008/06/13.