1-(2-Hydroxy-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane

Base Information

• Chemical Name: 1-(2-Hydroxy-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane
• CAS No.: 103560-69-6
• Molecular Formula: C17H20O4
• Molecular Weight: 288.343
• ChEMBL ID: CHEMBL1834920
• DSSTox Substance ID: DTXSID50554361
• Metabolomics Workbench ID: 125149
• Wikidata: Q27138046
• Mol file: 103560-69-6.mol

Synonyms:103560-69-6;1-(2-hydroxy-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane;4-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol;CHEBI:69704;CHEMBL1834920;DTXSID50554361;BDBM112639;Q27138046;1-(2-hydroxy-4-meth-oxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane (12)

Chemical Property of 1-(2-Hydroxy-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 288.13615911
• Heavy Atom Count: 21
• Complexity: 297

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)O)OC)O

Technology Process of 1-(2-Hydroxy-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane

There total 3 articles about 1-(2-Hydroxy-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-benzyloxy-2'-hydroxy-3,4'-dimethoxychalcone (95560-60-4) → 1-(2'-hydroxy-4'-methoxyphenyl)-3-(4''-hydroxy-3''-methyoxyphenyl)-propane (103560-69-6)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; chloroform; for 4h; under 2585.7 Torr;

DOI:10.1016/0031-9422(85)80049-2

Reference yield:

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) → 1-(2'-hydroxy-4'-methoxyphenyl)-3-(4''-hydroxy-3''-methyoxyphenyl)-propane (103560-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 17 percent

2: 80 percent / H₂, AcOH / 10 percent Pd/C / CHCl₃; ethanol / 4 h / 2585.7 Torr

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; chloroform;

DOI:10.1016/0031-9422(85)80049-2

Reference yield:

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) → 1-(2'-hydroxy-4'-methoxyphenyl)-3-(4''-hydroxy-3''-methyoxyphenyl)-propane (103560-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 17 percent

2: 80 percent / H₂, AcOH / 10 percent Pd/C / CHCl₃; ethanol / 4 h / 2585.7 Torr

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; chloroform;

DOI:10.1016/0031-9422(85)80049-2

upstream raw materials:

4-benzyloxy-2'-hydroxy-3,4'-dimethoxychalcone

1-(2-hydroxy-4-methoxyphenyl)ethanone

3-methoxy-4-(phenylmethoxy)benzaldehyde