Isoxazole, 4,5-dihydro-5-(1-naphthalenyl)-3-phenyl-

Base Information

• Chemical Name: Isoxazole, 4,5-dihydro-5-(1-naphthalenyl)-3-phenyl-
• CAS No.: 1035-92-3
• Molecular Formula: C19H15NO
• Molecular Weight: 273.334
• Mol file: 1035-92-3.mol

Synonyms:

Chemical Property of Isoxazole, 4,5-dihydro-5-(1-naphthalenyl)-3-phenyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoxazole, 4,5-dihydro-5-(1-naphthalenyl)-3-phenyl-

There total 5 articles about Isoxazole, 4,5-dihydro-5-(1-naphthalenyl)-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-vinylnaphthalene (826-74-4,29793-40-6) + N-hydroxy-1-phenylmethanesulfonamide → 5-(naphthalen-1-yl)-3-phenyl-4,5-dihydroisoxazole (1035-92-3)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); iodine; tetrabutylammonium periodite; In dichloromethane; at 20 ℃; for 10h; Irradiation; Inert atmosphere;

DOI:10.1055/s-0037-1609480

Reference yield:

1-((1S,2S)-2-Phenyl-cyclopropyl)-naphthalene (94257-46-2,142745-96-8) → 3-[1]naphthyl-5-phenyl-4,5-dihydro-isoxazole (142746-04-1) + 5-(naphthalen-1-yl)-3-phenyl-4,5-dihydroisoxazole (1035-92-3)

Guidance literature:

With nitrosonium tetrafluoroborate; In acetonitrile; for 0.5h; Title compound not separated from byproducts; Ambient temperature;

DOI:10.1021/jo00043a026

Reference yield:

3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one (80674-36-8,42299-49-0) → 5-(naphthalen-1-yl)-3-phenyl-4,5-dihydroisoxazole (1035-92-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; for 0.0152778h; Microwave irradiation;

DOI:10.1002/jhet.3752

upstream raw materials:

1-vinylnaphthalene

benzohydroximoyl chloride

1-((1S,2S)-2-Phenyl-cyclopropyl)-naphthalene

1-naphthaldehyde