1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-6-(4-hydroxyphenyl)-, hydrobromide

Base Information

• Chemical Name: 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-6-(4-hydroxyphenyl)-, hydrobromide
• CAS No.: 103692-33-7
• Molecular Formula: C16H17NO3.BrH
• Molecular Weight: 352.228
• Mol file: 103692-33-7.mol

Synonyms:

Chemical Property of 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-6-(4-hydroxyphenyl)-, hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-6-(4-hydroxyphenyl)-, hydrobromide

There total 9 articles about 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-6-(4-hydroxyphenyl)-, hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,3,4,5-tetrahydro-7,8-dimethoxy-6-(4-methoxyphenyl)-1H-3-benzazepine (103692-31-5) → 2,3,4,5-tetrahydro-6-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrobromide (103692-33-7)

Guidance literature:

With boron tribromide; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1021/jm00160a018

Reference yield:

4',5,6-trimethoxy-2-biphenylmethanol (99424-17-6) → 2,3,4,5-tetrahydro-6-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrobromide (103692-33-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 92 percent / conc. aq. HCl / toluene / 1 h / 100 °C

2: 95 percent / dimethylsulfoxide / 1 h / Ambient temperature

3: 98 percent / NH₃, H₂ / Raney Ni / methanol / 3 h / 50 °C / 2585.7 Torr

4: 88 percent / aq. NaOH / H₂O; toluene / 0.25 h

5: 33 percent / ethanol; H₂O / 22 h / Irradiation

6: 89 percent / BH₃ / tetrahydrofuran / 2 h / Heating

7: 70 percent / BBr₃ / CH₂Cl₂ / 18 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; borane; ammonia; hydrogen; boron tribromide; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

DOI:10.1021/jm00160a018

Reference yield:

2-(chloromethyl)-4',5,6-trimethoxybiphenyl (103692-15-5) → 2,3,4,5-tetrahydro-6-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrobromide (103692-33-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / dimethylsulfoxide / 1 h / Ambient temperature

2: 98 percent / NH₃, H₂ / Raney Ni / methanol / 3 h / 50 °C / 2585.7 Torr

3: 88 percent / aq. NaOH / H₂O; toluene / 0.25 h

4: 33 percent / ethanol; H₂O / 22 h / Irradiation

5: 89 percent / BH₃ / tetrahydrofuran / 2 h / Heating

6: 70 percent / BBr₃ / CH₂Cl₂ / 18 h / Ambient temperature

With sodium hydroxide; borane; ammonia; hydrogen; boron tribromide; nickel; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;

DOI:10.1021/jm00160a018

upstream raw materials:

2,3,4,5-tetrahydro-7,8-dimethoxy-6-(4-methoxyphenyl)-1H-3-benzazepine

4',5,6-trimethoxy-2-biphenylmethanol

2-(chloromethyl)-4',5,6-trimethoxybiphenyl

2-(cyanomethyl)-4',5,6-trimethoxybiphenyl