1-Azaspiro[4.5]deca-6,9-diene-2,8-dione, 1-methoxy-

Base Information

Chemical Name:1-Azaspiro[4.5]deca-6,9-diene-2,8-dione, 1-methoxy-
CAS No.:103831-04-5
Molecular Formula:C10H11NO3
Molecular Weight:193.202
Hs Code.:
Mol file:103831-04-5.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Azaspiro[4.5]deca-6,9-diene-2,8-dione, 1-methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Azaspiro[4.5]deca-6,9-diene-2,8-dione, 1-methoxy-

There total 1 articles about 1-Azaspiro[4.5]deca-6,9-diene-2,8-dione, 1-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.64%

: 112403-71-1
O-methyl N-chloro-3-(p-methoxyphenyl)propanohydroxamate

: 103831-04-5
N-methoxy-1-azaspiro<4,5>deca-6,9-diene-2,8-dione

: 103831-07-8
O-methyl 3-(p-methoxyphenyl)propanohydroxamate

: 112403-81-3
N-methoxy-6-methoxy-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: With silver tetrafluoroborate; In diethyl ether;
DOI:10.1016/S0040-4020(01)81665-3

Reference yield:

: 103831-04-5
N-methoxy-1-azaspiro<4,5>deca-6,9-diene-2,8-dione

: (5β,6β,7β,8α,10aβ)-octahydro-5-[(4-methoxy-phenyl)methyl]-1H-7,10a-methanopyrrolo[1,2-a]azocine-6,8-diol

Guidance literature:: Multi-step reaction with 14 steps

1.1: H₂ / Pd/C / ethyl acetate / 20 h / 20 °C / 760.05 Torr

2.1: PPTS / benzene / 3.5 h / Heating

3.1: 5.18 g / Na; liq.NH₃ / tetrahydrofuran; liquid ammonia / 0.5 h / -78 °C

4.1: NaH / dimethylformamide; various solvent(s) / 3 h / 0 °C

4.2: dimethylformamide; various solvent(s) / 4 h / 0 °C

5.1: 104.3 mg / aq. HCl / acetone / 18 h / 50 °C

6.1: (Me₃Si)2NH / CH₂Cl₂ / 0.5 h / 20 °C

6.2: CH₂Cl₂ / 2 h / 20 °C

7.1: AIBN; tributylstannane / benzene / 4.5 h / 80 °C

7.2: 10.8 mg / aq. HCl / methanol / 2 h / 20 °C

8.1: NaH; Bu₄NI / dimethylformamide; various solvent(s) / 6 h / 20 °C

9.1: OsO₄; pyridine / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 0.5 h / 20 °C

9.2: 433.2 mg / NaIO₄ / H₂O; 2-methyl-propan-2-ol; tetrahydrofuran / 6 h / 20 °C

10.1: KHMDS / tetrahydrofuran / 0.25 h / -50 °C

10.2: tetrahydrofuran / 0.67 h / -78 °C

11.1: 20.1 mg / ZnCl₂*OEt₂ / diethyl ether; CH₂Cl₂ / 16 h / -25 °C

12.1: 85 percent / SmI₂; water / tetrahydrofuran / 0.08 h / 20 °C

13.1: 28 percent / LiAlH₄ / tetrahydrofuran / 22 h / -78 - 20 °C

14.1: 99 percent / H₂ / Pd(OH)2/C / methanol / 3 h / 20 °C / 760.05 Torr

With pyridine; hydrogenchloride; osmium(VIII) oxide; lithium aluminium tetrahydride; samarium diiodide; zinc chloride diethyl ether; 2,2'-azobis(isobutyronitrile); ammonia; water; hydrogen; tri-n-butyl-tin hydride; sodium; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ammonia; water; ethyl acetate; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/ol0161514

Reference yield:

: 103831-04-5
N-methoxy-1-azaspiro<4,5>deca-6,9-diene-2,8-dione

: (5β,6β,7β,8α,10aβ)-octahydro-8-benzyloxy-6-hydroxy-5-[(4-methoxy-phenyl)methyl]-1H-7,10a-methanopyrrolo[1,2-a]azocine-3-one

Guidance literature:: Multi-step reaction with 12 steps

1.1: H₂ / Pd/C / ethyl acetate / 20 h / 20 °C / 760.05 Torr

2.1: PPTS / benzene / 3.5 h / Heating

3.1: 5.18 g / Na; liq.NH₃ / tetrahydrofuran; liquid ammonia / 0.5 h / -78 °C

4.1: NaH / dimethylformamide; various solvent(s) / 3 h / 0 °C

4.2: dimethylformamide; various solvent(s) / 4 h / 0 °C

5.1: 104.3 mg / aq. HCl / acetone / 18 h / 50 °C

6.1: (Me₃Si)2NH / CH₂Cl₂ / 0.5 h / 20 °C

6.2: CH₂Cl₂ / 2 h / 20 °C

7.1: AIBN; tributylstannane / benzene / 4.5 h / 80 °C

7.2: 10.8 mg / aq. HCl / methanol / 2 h / 20 °C

8.1: NaH; Bu₄NI / dimethylformamide; various solvent(s) / 6 h / 20 °C

9.1: OsO₄; pyridine / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 0.5 h / 20 °C

9.2: 433.2 mg / NaIO₄ / H₂O; 2-methyl-propan-2-ol; tetrahydrofuran / 6 h / 20 °C

10.1: KHMDS / tetrahydrofuran / 0.25 h / -50 °C

10.2: tetrahydrofuran / 0.67 h / -78 °C

11.1: 20.1 mg / ZnCl₂*OEt₂ / diethyl ether; CH₂Cl₂ / 16 h / -25 °C

12.1: 85 percent / SmI₂; water / tetrahydrofuran / 0.08 h / 20 °C

With pyridine; hydrogenchloride; osmium(VIII) oxide; samarium diiodide; zinc chloride diethyl ether; 2,2'-azobis(isobutyronitrile); ammonia; water; hydrogen; tri-n-butyl-tin hydride; sodium; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium hydride; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ammonia; water; ethyl acetate; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/ol0161514