3-Amino-6-fluorobiphenyl

Base Information

Chemical Name:3-Amino-6-fluorobiphenyl
CAS No.:103977-88-4
Molecular Formula:C12H10FN
Molecular Weight:187.21300
Hs Code.:
DSSTox Substance ID:DTXSID60470245
Wikidata:Q82298262
Mol file:103977-88-4.mol

Synonyms:103977-88-4;4-Fluoro-3-phenylaniline;6-Fluoro-[1,1'-biphenyl]-3-amine;3-amino-6-fluorobiphenyl;[1,1'-Biphenyl]-3-amine, 6-fluoro-;6-Fluoro-biphenyl-3-amine;SCHEMBL3787110;DTXSID60470245;KGHJSTHVTOSNLM-UHFFFAOYSA-N;MFCD14701579;F13916;EN300-2687137

Suppliers and Price of 3-Amino-6-fluorobiphenyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Fluoro-[1,1'-biphenyl]-3-amine 95+%
1g
$ 474.00

Alichem
5-Amino-2-fluorobiphenyl
1g
$ 1519.80

Alichem
5-Amino-2-fluorobiphenyl
500mg
$ 863.90

Alichem
5-Amino-2-fluorobiphenyl
250mg
$ 504.00

Acrotein
6-Fluoro-biphenyl-3-amine 97%
1g
$ 458.30

Acrotein
6-Fluoro-biphenyl-3-amine 97%
0.5g
$ 302.50

Total 3 raw suppliers

Chemical Property of 3-Amino-6-fluorobiphenyl

Chemical Property:

PSA：26.02000
LogP:3.65610
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:187.079727485
Heavy Atom Count:14
Complexity:177

Purity/Quality:

99% ^*data from raw suppliers

6-Fluoro-[1,1'-biphenyl]-3-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(C=CC(=C2)N)F

Technology Process of 3-Amino-6-fluorobiphenyl

There total 4 articles about 3-Amino-6-fluorobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: tin(II)chloride dihydrate

: 103977-87-3
2-fluoro-5-nitro-1-phenylbenzene

: 103977-88-4
4-fluoro-3-phenylaniline

Guidance literature:: With hydrogenchloride; In water;

Reference yield:

: 103977-87-3
2-fluoro-5-nitro-1-phenylbenzene

: 103977-88-4
4-fluoro-3-phenylaniline

Guidance literature:: With tin(II) chloride dihdyrate; In ethyl acetate; for 2.5h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.08.015

Reference yield:

: (2-fluoro-5-nitrophenyl)boronic acid

: 103977-88-4
4-fluoro-3-phenylaniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: barium hydroxide octahydrate / 1,2-dimethoxyethane; water / 0.25 h / Inert atmosphere

1.2: Reflux; Inert atmosphere

2.1: tin(II) chloride dihdyrate / ethyl acetate / 2.5 h / Reflux; Inert atmosphere

With tin(II) chloride dihdyrate; barium hydroxide octahydrate; In 1,2-dimethoxyethane; water; ethyl acetate; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.08.015