Diethyl 2,6-dimethyl-4-(5-(2-nitrophenyl)furan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:Diethyl 2,6-dimethyl-4-(5-(2-nitrophenyl)furan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:104024-40-0
Molecular Formula:C23H24N2O7
Molecular Weight:440.453
Hs Code.:
European Community (EC) Number:632-277-4
Mol file:104024-40-0.mol

Synonyms:Diethyl 2,6-dimethyl-4-(5-(2-nitrophenyl)furan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate;diethyl 2,6-dimethyl-4-[5-(2-nitrophenyl)furan-2-yl]-1,4-dihydropyridine-3,5-dicarboxylate;104024-40-0;Oprea1_114913;STK808941;AKOS001665539;Diethyl 2,6-dimethyl-4-[5-(2-nitrophenyl)-2-furyl]-1,4-dihydropyridine-3,5-dicarboxylate;EU-0078219;SR-01000492800;SR-01000492800-1;Z90443458;diethyl 2,6-dimethyl-4-[5-(2-nitrophenyl)-2-furyl]-1,4-dihydro-3,5-pyridinedicarboxylate

Suppliers and Price of Diethyl 2,6-dimethyl-4-(5-(2-nitrophenyl)furan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
DIETHYL 2,6-DIMETHYL-4-[5-(2-NITROPHENYL)-2-FURYL]-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE 95.00%
5MG
$ 496.74

Total 0 raw suppliers

Chemical Property of Diethyl 2,6-dimethyl-4-(5-(2-nitrophenyl)furan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

PSA：123.59000
LogP:5.06780
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:440.15835111
Heavy Atom Count:32
Complexity:774

Purity/Quality:: DIETHYL 2,6-DIMETHYL-4-[5-(2-NITROPHENYL)-2-FURYL]-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C2=CC=C(O2)C3=CC=CC=C3[N+](=O)[O-])C(=O)OCC)C)C

Technology Process of Diethyl 2,6-dimethyl-4-(5-(2-nitrophenyl)furan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate

There total 2 articles about Diethyl 2,6-dimethyl-4-(5-(2-nitrophenyl)furan-2-yl)-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 20000-96-8
5-(2-nitrophenyl)-2-furaldehyde

: 141-97-9
ethyl acetoacetate

: 104024-40-0
diethyl 2,6-dimethyl-4-[5'-(2''-nitrophenyl)furan-2-yl]-1,4-dihydropyridine-3-carboxylate

Guidance literature:: With ammonium hydroxide; In methanol; for 6h; Heating;

Reference yield:

: 98-01-1
furfural

: 88-74-4
2-nitro-aniline

: 104024-40-0
diethyl 2,6-dimethyl-4-[5'-(2''-nitrophenyl)furan-2-yl]-1,4-dihydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; copper dichloride / water / -5 °C

2: ammonium acetate / ethanol / 6 h / Reflux

With hydrogenchloride; ammonium acetate; copper dichloride; In ethanol; water; 1: |Meerwein Arylation / 2: |Hantzsch Dihydropyridine Synthesis;
DOI:10.14233/ajchem.2017.20199