2-ethoxy-3,4-dihydro-2H-chroMene

Base Information

• Chemical Name: 2-ethoxy-3,4-dihydro-2H-chroMene
• CAS No.: 10419-35-9
• Molecular Formula: C11H14O2
• Molecular Weight: 178.22800
• Hs Code.: 2932999099
• Mol file: 10419-35-9.mol

Synonyms:2-ethoxychroman;2-ethoxychromane;2-Aethoxy-chroman;2H-1-Benzopyran,2-ethoxy-3,4-dihydro;

Chemical Property of 2-ethoxy-3,4-dihydro-2H-chroMene

Chemical Property:

• PSA: 18.46000
• LogP: 2.37420

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Ethoxy-3,4-dihydro-2H-chromene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethoxy-3,4-dihydro-2H-chroMene

There total 2 articles about 2-ethoxy-3,4-dihydro-2H-chroMene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

o-(methylthiomethyl)-phenol (4526-41-4) + ethyl vinyl ether (109-92-2,25104-37-4) → 2-ethoxy-3,4-dihydro-2H-chromene (10419-35-9) + 2-<2-(methylthiomethyl)phenoxymethyl>phenol (124313-15-1)

Guidance literature:

With silver(l) oxide; for 18h; Ambient temperature; further oxidizing agents e.g.: HgO, AgOac, Hg(Oac)2 and AgNO₃;

DOI:10.1246/bcsj.63.1062

Reference yield:

2-Hydroxybenzylamine (932-30-9) + ethyl vinyl ether (109-92-2,25104-37-4) → 2-((2-methyl-2H-benzo[e][1.3]oxazin-3(4H)-yl)methyl)phenol + 2-ethoxy-3,4-dihydro-2H-chromene (10419-35-9)

Guidance literature:

at 100 ℃;

DOI:10.1021/jo052621m

Reference yield:

2-ethoxy-3,4-dihydro-2H-chromene (10419-35-9) → o-(3-Aethoxyheptyl)-anisol (19346-80-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 105 °C

2: NaOMe

With sodium methylate; In toluene;

upstream raw materials:

o-(methylthiomethyl)-phenol

ethyl vinyl ether

2-Hydroxybenzylamine

Downstream raw materials:

o-(3-Aethoxyheptyl)-phenyl

o-(3-Aethoxy-pentyl)-phenol

o-(3-Aethoxyheptyl)-anisol

Refernces

• 1、 Inoue,Inoue,Sato. "A new synthesis of o-quinonemethides and their inter- and intramolecular cyclization reactions". . p. 1062 - 1068. Retrieved 2007/10/02.