5,6-Dihydro-6-(4-methoxyphenyl)-3-methyl-4H-pyrrolo(1,2-a)thieno(3,2-f)(1,4)diazepine

Base Information

Chemical Name:5,6-Dihydro-6-(4-methoxyphenyl)-3-methyl-4H-pyrrolo(1,2-a)thieno(3,2-f)(1,4)diazepine
CAS No.:137052-98-3
Molecular Formula:C₁₈H₁₈N₂OS
Molecular Weight:310.42
Hs Code.:
DSSTox Substance ID:DTXSID50929696
Nikkaji Number:J618.400F
Mol file:137052-98-3.mol

Synonyms:5,6-Dihydro-6-(4-methoxyphenyl)-3-methyl-4H-pyrrolo(1,2-a)thieno(3,2-f)(1,4)diazepine;4H-Pyrrolo(1,2-a)thieno(3,2-f)(1,4)diazepine, 5,6-dihydro-6-(4-methoxyphenyl)-3-methyl-;137052-98-3;DTXSID50929696;LS-139746;3-Methyl-5,6-dihydro-6-(4-methoxyphenyl)-4H-pyrrolo[1,2-a]thieno[3,2-f][1,4]diazepine;6-(4-Methoxyphenyl)-3-methyl-5,6-dihydro-4H-pyrrolo[1,2-a]thieno[3,2-f][1,4]diazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,6-Dihydro-6-(4-methoxyphenyl)-3-methyl-4H-pyrrolo(1,2-a)thieno(3,2-f)(1,4)diazepine

Chemical Property:

Vapor Pressure:9.47E-10mmHg at 25°C
Boiling Point:490°C at 760 mmHg
Flash Point:250.2°C
Density:1.27g/cm³
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:310.11398438
Heavy Atom Count:22
Complexity:385

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CSC2=C1CNC(C3=CC=CN32)C4=CC=C(C=C4)OC

Technology Process of 5,6-Dihydro-6-(4-methoxyphenyl)-3-methyl-4H-pyrrolo(1,2-a)thieno(3,2-f)(1,4)diazepine

There total 4 articles about 5,6-Dihydro-6-(4-methoxyphenyl)-3-methyl-4H-pyrrolo(1,2-a)thieno(3,2-f)(1,4)diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 160916-18-7
1-<2-(3-p-methoxy-benzylideneaminomethyl-4-methyl)thien-2-yl>pyrrole

: 137052-98-3
6-(4-Methoxy-phenyl)-3-methyl-5,6-dihydro-4H-1-thia-5,9a-diaza-cyclopenta[e]azulene

Guidance literature:: With hydrogenchloride; sodium hydroxide; ethanol; water; for 0.75h; Ambient temperature;
DOI:10.1002/ardp.19943271108

Reference yield:

: 4623-55-6
2-amino-4-methylthiophene-3-carbonitrile

: 137052-98-3
6-(4-Methoxy-phenyl)-3-methyl-5,6-dihydro-4H-1-thia-5,9a-diaza-cyclopenta[e]azulene

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / glacial acetic acid / 0.5 h / Heating

2: 91 percent / LiAlH₄ / diethyl ether / 24 h / Heating

3: 77 percent / ethanol / 0.25 h / Heating

4: 65 percent / 1.) saturated HCl/EtOH, 2.) dil. NaOH/H₂O / 0.75 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; ethanol; water; acetic acid; In diethyl ether; ethanol;
DOI:10.1002/ardp.19943271108

Reference yield:

: 160916-15-4
1-<2-(3-aminomethyl-4-methyl)thien-2-yl>pyrrole

: 137052-98-3
6-(4-Methoxy-phenyl)-3-methyl-5,6-dihydro-4H-1-thia-5,9a-diaza-cyclopenta[e]azulene

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / ethanol / 0.25 h / Heating

2: 65 percent / 1.) saturated HCl/EtOH, 2.) dil. NaOH/H₂O / 0.75 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; ethanol; water; In ethanol;
DOI:10.1002/ardp.19943271108