1-(4-Azido-3-nitrophenyl)ethan-1-one

Base Information

• Chemical Name: 1-(4-Azido-3-nitrophenyl)ethan-1-one
• CAS No.: 104503-83-5
• Molecular Formula: C8H6N4O3
• Molecular Weight: 206.161
• DSSTox Substance ID: DTXSID10544162
• Wikidata: Q82421182
• Mol file: 104503-83-5.mol

Synonyms:104503-83-5;1-(4-Azido-3-nitrophenyl)ethan-1-one;DTXSID10544162

Chemical Property of 1-(4-Azido-3-nitrophenyl)ethan-1-one

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 206.04399007
• Heavy Atom Count: 15
• Complexity: 318

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC(=C(C=C1)N=[N+]=[N-])[N+](=O)[O-]

Technology Process of 1-(4-Azido-3-nitrophenyl)ethan-1-one

There total 1 articles about 1-(4-Azido-3-nitrophenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-chloro-3-nitroacetophenone (5465-65-6) → 4-acetyl-2-nitroazidobenzene (104503-83-5)

Guidance literature:

With sodium azide; benzyl tri-n-butylammonium bromide; In 1,2-dichloro-ethane; at 50 ℃; for 6h;

DOI:10.1055/s-1987-28023

Reference yield: 18.0%

4-acetyl-2-nitroazidobenzene (104503-83-5) → 1-(4-amino-3-nitrophenyl)ethanone (1432-42-4) + 1-(4-Acetyl-2-nitro-phenyl)-5-ethoxycarbonylmethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (210989-46-1) + 5-acetylbenzofurazan oxide (66194-29-4)

Guidance literature:

With diethyl acetylmalonate; sodium ethanolate; In ethanol; at 0 - 5 ℃;

DOI:10.1016/S0014-827X(98)00025-1

Reference yield:

4-acetyl-2-nitroazidobenzene (104503-83-5) → 1-(4-Acetyl-2-amino-phenyl)-5-ethoxycarbonylmethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (210989-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 18 percent / NaOEt, diethyl acetonedicarboxylate / ethanol / 0 - 5 °C

2: 95 percent / Fe, FeCl₃, H₂O / ethanol / 3 h / Heating

With diethyl acetylmalonate; water; sodium ethanolate; iron(III) chloride; iron; In ethanol;

DOI:10.1016/S0014-827X(98)00025-1

upstream raw materials:

4-chloro-3-nitroacetophenone

Downstream raw materials:

1-(4-amino-3-nitrophenyl)ethanone

1-(4-Acetyl-2-nitro-phenyl)-5-ethoxycarbonylmethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester

5-acetylbenzofurazan oxide

1-(4-Acetyl-2-amino-phenyl)-5-ethoxycarbonylmethyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester