2-{4-[(2S,3R)-2-[(tert-butoxycarbonyl)amino]-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxybutyl]phenoxy}ethyl dimethylcarbamate

Base Information

Chemical Name:2-{4-[(2S,3R)-2-[(tert-butoxycarbonyl)amino]-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxybutyl]phenoxy}ethyl dimethylcarbamate
CAS No.:162541-14-2
Molecular Formula:C₃₅H₅₄N₄O₉
Molecular Weight:674.835
Hs Code.:

2-{4-[(2S,3R)-2-[(tert-butoxycarbonyl)amino]-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxybutyl]phenoxy}ethyl dimethylcarbamate

Synonyms:12-Oxa-2,6,10-triazatetradecanoicacid,3-[[4-[2-[[(dimethylamino)carbonyl]oxy]ethoxy]phenyl]methyl]-4,8-dihydroxy-13,13-dimethyl-11-oxo-9-(phenylmethyl)-,1,1-dimethylethyl ester, [3S-(3R*,4S*,8S*,9R*)]-

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Chemical Property of 2-{4-[(2S,3R)-2-[(tert-butoxycarbonyl)amino]-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxybutyl]phenoxy}ethyl dimethylcarbamate

Chemical Property:

Vapor Pressure:3.48E-27mmHg at 25°C
Boiling Point:802.5°C at 760 mmHg
Flash Point:439.2°C
Density:1.167g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-{4-[(2S,3R)-2-[(tert-butoxycarbonyl)amino]-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxybutyl]phenoxy}ethyl dimethylcarbamate

There total 9 articles about 2-{4-[(2S,3R)-2-[(tert-butoxycarbonyl)amino]-4-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}amino)-3-hydroxybutyl]phenoxy}ethyl dimethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 246047-29-0
((S)-3-Amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert-butyl ester

: {(S)-2-[4-(2-Dimethylcarbamoyloxy-ethoxy)-phenyl]-1-oxiranyl-ethyl}-carbamic acid tert-butyl ester

: 162541-14-2
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-1-[4-(2-dimethylcarbamoyloxy-ethoxy)-benzyl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 4h;
DOI:10.1021/jm950717a

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 162541-14-2
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-1-[4-(2-dimethylcarbamoyloxy-ethoxy)-benzyl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 4-methylmorpholine / tetrahydrofuran

2: tetrahydrofuran; diethyl ether / 0 °C

3: HCl / dioxane / 0 °C

4: NaBH₄

5: KOH / ethanol

6: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

7: 35 percent / DEAD, Ph₃P / tetrahydrofuran / Ambient temperature

8: 33 percent / dimethylformamide / 4 h / 100 °C

With 4-methyl-morpholine; hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a

Reference yield:

: 1026977-99-0
C₂₆H₃₃NO₇

: 162541-14-2
{(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-1-[4-(2-dimethylcarbamoyloxy-ethoxy)-benzyl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: tetrahydrofuran; diethyl ether / 0 °C

2: HCl / dioxane / 0 °C

3: NaBH₄

4: KOH / ethanol

5: 99 percent / H₂, Pd(OH)2/C / ethanol; ethyl acetate / 4.5 h

6: 35 percent / DEAD, Ph₃P / tetrahydrofuran / Ambient temperature

7: 33 percent / dimethylformamide / 4 h / 100 °C

With hydrogenchloride; palladium dihydroxide; potassium hydroxide; sodium tetrahydroborate; hydrogen; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a