2-{2-[(2,2-dimethylpropanoyl)amino]-6-oxo-3,6-dihydropyrimidin-4-yl}-2-oxoethyl chloroacetate

Base Information

Chemical Name:2-{2-[(2,2-dimethylpropanoyl)amino]-6-oxo-3,6-dihydropyrimidin-4-yl}-2-oxoethyl chloroacetate
CAS No.:86944-44-7
Molecular Formula:C₁₃H₁₆ClN₃O₅
Molecular Weight:329.74
Hs Code.:

Synonyms:Aceticacid, chloro-, 2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-1,6-dihydro-6-oxo-4-pyrimidinyl]-2-oxoethylester (9CI)

Suppliers and Price of 2-{2-[(2,2-dimethylpropanoyl)amino]-6-oxo-3,6-dihydropyrimidin-4-yl}-2-oxoethyl chloroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{2-[(2,2-dimethylpropanoyl)amino]-6-oxo-3,6-dihydropyrimidin-4-yl}-2-oxoethyl chloroacetate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.4g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-{2-[(2,2-dimethylpropanoyl)amino]-6-oxo-3,6-dihydropyrimidin-4-yl}-2-oxoethyl chloroacetate

There total 3 articles about 2-{2-[(2,2-dimethylpropanoyl)amino]-6-oxo-3,6-dihydropyrimidin-4-yl}-2-oxoethyl chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 86944-29-8
2-pivalamido-6-(bromoacetyl)-4(1H)-pyrimidinone

: 79-11-8
chloroacetic acid

: 86944-44-7
2-pivalamido-6-<(chloroacetoxy)acetyl>-4(1H)-pyrimidinone

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃; for 2h;
DOI:10.1021/jo00169a001

Reference yield:

: 86944-28-7
2-pivalamido-6-(1-ethoxyvinyl)-4(1H)-pyrimidinone

: 86944-44-7
2-pivalamido-6-<(chloroacetoxy)acetyl>-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NBS / H₂O; acetone / Heating

2: 29 percent / NaH / dimethylformamide / 2 h / 100 °C

With N-Bromosuccinimide; sodium hydride; In water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00169a001

Reference yield:

: 86944-27-6
2-pivalamido-6-(1,1-diethoxyethyl)-4(1H)-pyrimidinone

: 86944-44-7
2-pivalamido-6-<(chloroacetoxy)acetyl>-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / toluenesulfonic acid / xylene / 0.25 h / Heating

2: 90 percent / NBS / H₂O; acetone / Heating

3: 29 percent / NaH / dimethylformamide / 2 h / 100 °C

With N-Bromosuccinimide; o-toluenesulfonic acid; sodium hydride; In water; N,N-dimethyl-formamide; acetone; xylene;
DOI:10.1021/jo00169a001