Thiopyrano(2,3-b)indole-9-carboxylic acid, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-, methyl ester, monohydrochloride

Base Information

Chemical Name:Thiopyrano(2,3-b)indole-9-carboxylic acid, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-, methyl ester, monohydrochloride
CAS No.:73426-20-7
Molecular Formula:C₁₅H₁₈N₂O₂S*ClH
Molecular Weight:326.847
Hs Code.:
DSSTox Substance ID:DTXSID50994187

Synonyms:73426-20-7;Thiopyrano(2,3-b)indole-9-carboxylic acid, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-, methyl ester, monohydrochloride;C15H18N2O2S.ClH;DTXSID50994187;C15-H18-N2-O2-S.Cl-H;LS-153258;4-[2-(Methylamino)ethyl]-3,4-dihydrothiopyrano[2,3-b]indole-9(2H)-carboxylic acid--hydrogen chloride (1/1)

Suppliers and Price of Thiopyrano(2,3-b)indole-9-carboxylic acid, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-, methyl ester, monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thiopyrano(2,3-b)indole-9-carboxylic acid, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-, methyl ester, monohydrochloride

Chemical Property:

Vapor Pressure:1.62E-10mmHg at 25°C
Boiling Point:492.5°C at 760 mmHg
Flash Point:251.7°C
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:326.0855767
Heavy Atom Count:21
Complexity:366

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNCCC1CCSC2=C1C3=CC=CC=C3N2C(=O)O.Cl

Technology Process of Thiopyrano(2,3-b)indole-9-carboxylic acid, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-, methyl ester, monohydrochloride

There total 3 articles about Thiopyrano(2,3-b)indole-9-carboxylic acid, 2,3,4,9-tetrahydro-4-((methylamino)methyl)-, methyl ester, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[(tert-Butoxycarbonyl-methyl-amino)-methyl]-3,4-dihydro-2H-thiopyrano[2,3-b]indole-9-carboxylic acid methyl ester

: 73426-20-7
4-Methylaminomethyl-3,4-dihydro-2H-thiopyrano[2,3-b]indole-9-carboxylic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; trifluoroacetic acid; In dichloromethane; for 2h; Yield given;
DOI:10.1248/cpb.32.877

Reference yield:

: 73425-49-7
4-aminomethyl-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole

: 73426-20-7
4-Methylaminomethyl-3,4-dihydro-2H-thiopyrano[2,3-b]indole-9-carboxylic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

2: 1) 50 percent NaH / 1.) oil, DMF, RT, 1 h; 2.) DMF, oil

3: 1) CF₃COOH; 2) HCl / CH₂Cl₂ / 2 h

With hydrogenchloride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.32.877

Reference yield:

: 73425-25-9
4-(N-tert-butoxycarbonyl-N-methylaminomethyl)-2,3,4,9-tetrahydrothiopyrano<2,3-b>indole

: 73426-20-7
4-Methylaminomethyl-3,4-dihydro-2H-thiopyrano[2,3-b]indole-9-carboxylic acid methyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1) 50 percent NaH / 1.) oil, DMF, RT, 1 h; 2.) DMF, oil

2: 1) CF₃COOH; 2) HCl / CH₂Cl₂ / 2 h

With hydrogenchloride; sodium hydride; trifluoroacetic acid; In dichloromethane;
DOI:10.1248/cpb.32.877