Technology Process of Cubebin
There total 11 articles about Cubebin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
dichloromethane;
at -78 ℃;
for 0.333333h;
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
dichloromethane; cyclohexane;
at -78 ℃;
for 0.333333h;
Overall yield = 56 %; Overall yield = 0.432 g; diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b02644
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: fetizon's reagent / toluene / 1.5 h / Inert atmosphere; Reflux
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 23 h / 20 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / dichloromethane; cyclohexane / 0.33 h / -78 °C / Inert atmosphere
With
diisobutylaluminium hydride; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; cyclohexane; toluene;
DOI:10.1021/acs.orglett.7b02644
