4-[5-(4-Methylphenyl)-1,3-oxazol-2-yl]benzamide

Base Information

Chemical Name:4-[5-(4-Methylphenyl)-1,3-oxazol-2-yl]benzamide
CAS No.:108783-86-4
Molecular Formula:C17H14N2O2
Molecular Weight:278.31
Hs Code.:
DSSTox Substance ID:DTXSID50545330
Wikidata:Q82422786
Mol file:108783-86-4.mol

Synonyms:108783-86-4;4-(5-(p-Tolyl)oxazol-2-yl)benzamide;4-[5-(4-Methylphenyl)-1,3-oxazol-2-yl]benzamide;DTXSID50545330

Suppliers and Price of 4-[5-(4-Methylphenyl)-1,3-oxazol-2-yl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[5-(4-Methylphenyl)-1,3-oxazol-2-yl]benzamide

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:278.105527694
Heavy Atom Count:21
Complexity:358

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=CN=C(O2)C3=CC=C(C=C3)C(=O)N

Technology Process of 4-[5-(4-Methylphenyl)-1,3-oxazol-2-yl]benzamide

There total 6 articles about 4-[5-(4-Methylphenyl)-1,3-oxazol-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 108783-80-8
Acid Chloride of 2-(4-Carboxyphenyl)-5-(4-methylphenyl)oxazole

: 108783-86-4
2-(4-Carbamidophenyl)-5-(4-methylphenyl)oxazole

Guidance literature:: With ammonium hydroxide; In benzene; at 20 ℃;
DOI:10.1007/BF00478139

Reference yield:

: 5467-70-9
2-amino-4'-methylacetophenone hydrochloride

: 108783-86-4
2-(4-Carbamidophenyl)-5-(4-methylphenyl)oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 10percent aq. Na₂CO₃ / benzene; H₂O / 1 h / 25 °C

2: conc. H₂SO₄ / 2 h / 25 °C

3: 80 percent / aq. NaOH / acetone / 3 h / Heating

4: SOCl₂

5: 96 percent / 10percent aq. NH₃ / benzene / 20 °C

With ammonium hydroxide; sodium hydroxide; thionyl chloride; sulfuric acid; sodium carbonate; In water; acetone; benzene;
DOI:10.1007/BF00478139

Reference yield:

: 108783-74-0
2-(4-Carboxyphenyl)-5-(4-methylphenyl)oxazole

: 108783-86-4
2-(4-Carbamidophenyl)-5-(4-methylphenyl)oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂

2: 96 percent / 10percent aq. NH₃ / benzene / 20 °C

With ammonium hydroxide; thionyl chloride; In benzene;
DOI:10.1007/BF00478139