6-(2-Azidophenyl)-5,8-dimethylisoquinoline

Base Information

Chemical Name:6-(2-Azidophenyl)-5,8-dimethylisoquinoline
CAS No.:109855-81-4
Molecular Formula:C17H14N4
Molecular Weight:274.325
Hs Code.:
DSSTox Substance ID:DTXSID30550346
Wikidata:Q82429637
Mol file:109855-81-4.mol

Synonyms:109855-81-4;6-(2-Azidophenyl)-5,8-dimethylisoquinoline;DTXSID30550346

Suppliers and Price of 6-(2-Azidophenyl)-5,8-dimethylisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(2-Azidophenyl)-5,8-dimethylisoquinoline

Chemical Property:

XLogP3:5.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:274.121846464
Heavy Atom Count:21
Complexity:404

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C2=C1C=NC=C2)C)C3=CC=CC=C3N=[N+]=[N-]

Technology Process of 6-(2-Azidophenyl)-5,8-dimethylisoquinoline

There total 3 articles about 6-(2-Azidophenyl)-5,8-dimethylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: C₂₁H₂₂N₄

: 109855-81-4
6-(2-Azido-phenyl)-5,8-dimethyl-isoquinoline

Guidance literature:: With potassium hydrogensulfate; sodium azide; In dichloromethane; water; at 20 ℃; for 12h;
DOI:10.1021/jo070774z

Reference yield:

: 615-43-0
2-iodophenylamine

: 109855-81-4
6-(2-Azido-phenyl)-5,8-dimethyl-isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: conc. HCl; sodium nitrite / H₂O / 0.5 h / 0 °C

1.2: 92 percent / potassium carbonate / H₂O; acetonitrile / 0 - 20 °C

2.1: i-PrMgCl*LiCl / tetrahydrofuran / 1 h / -40 °C

2.2: ZnBr₂ / tetrahydrofuran / 1 h / -40 - -5 °C

2.3: 78 percent / Pd(PPh₃)4 / tetrahydrofuran / Heating

3.1: 95 percent / potassium hydrogen sulfate; sodium azide / CH₂Cl₂; H₂O / 12 h / 20 °C

With hydrogenchloride; potassium hydrogensulfate; TurboGrignard; sodium azide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; 2.3: Negishi cross-coupling;
DOI:10.1021/jo070774z

Reference yield:

: 250160-25-9
N,N-tetramethylene-N'-(2'-iodophenyl)triazene

: 109855-81-4
6-(2-Azido-phenyl)-5,8-dimethyl-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: i-PrMgCl*LiCl / tetrahydrofuran / 1 h / -40 °C

1.2: ZnBr₂ / tetrahydrofuran / 1 h / -40 - -5 °C

1.3: 78 percent / Pd(PPh₃)4 / tetrahydrofuran / Heating

2.1: 95 percent / potassium hydrogen sulfate; sodium azide / CH₂Cl₂; H₂O / 12 h / 20 °C

With potassium hydrogensulfate; TurboGrignard; sodium azide; In tetrahydrofuran; dichloromethane; water; 1.3: Negishi cross-coupling;
DOI:10.1021/jo070774z