Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(4-methoxybenzoyl )-, 3'-[O-(2-cyanoethyl) S-(1,1-dimethylethyl) phosphorothioite]

Base Information

• Chemical Name: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(4-methoxybenzoyl )-, 3'-[O-(2-cyanoethyl) S-(1,1-dimethylethyl) phosphorothioite]
• CAS No.: 109875-56-1
• Molecular Formula: C₄₅H₄₉N₄O₉PS
• Molecular Weight: 852.945

Synonyms:

Chemical Property of Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(4-methoxybenzoyl )-, 3'-[O-(2-cyanoethyl) S-(1,1-dimethylethyl) phosphorothioite]

Chemical Property:

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Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(4-methoxybenzoyl )-, 3'-[O-(2-cyanoethyl) S-(1,1-dimethylethyl) phosphorothioite]

There total 1 articles about Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(4-methoxybenzoyl )-, 3'-[O-(2-cyanoethyl) S-(1,1-dimethylethyl) phosphorothioite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N4-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine (68892-40-0) + (t-butylthio) β-cyanoethoxychlorophosphine (109875-52-7) → Thiophosphorous acid O-{(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[4-(4-methoxy-benzoylamino)-2-oxo-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl} ester S-tert-butyl ester O'-(2-cyano-ethyl) ester (109875-56-1)

Guidance literature:

With pyridine; for 0.166667h;

DOI:10.1016/S0040-4039(00)95947-1

upstream raw materials:

N⁴-anisoyl-5'-O-(4,4'-dimethoxytrityl) 2'-deoxy cytidine

(t-butylthio) β-cyanoethoxychlorophosphine

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