Methyl 6-amino-7-methoxy-2H-1,3-benzodioxole-5-carboxylate

Base Information

Chemical Name:Methyl 6-amino-7-methoxy-2H-1,3-benzodioxole-5-carboxylate
CAS No.:109893-05-2
Molecular Formula:C₁₀H₁₁NO₅
Molecular Weight:225.201
Hs Code.:
DSSTox Substance ID:DTXSID50573810
Wikidata:Q82462638
Mol file:109893-05-2.mol

Synonyms:109893-05-2;Methyl 6-amino-7-methoxy-2H-1,3-benzodioxole-5-carboxylate;Methyl 6-amino-7-methoxy-1,3-benzodioxole-5-carboxylate;1,3-Benzodioxole-5-carboxylic acid, 6-amino-7-methoxy-, methyl ester;Anthranilic acid, 3-methoxy-4,5-methylenedioxy-, methyl ester (6CI);Anthranilicacid,3-methoxy-4,5-methylenedioxy-,methylester(6CI);SCHEMBL17714992;DTXSID50573810;AKOS015899220;J-519593

Suppliers and Price of Methyl 6-amino-7-methoxy-2H-1,3-benzodioxole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methyl 6-amino-7-methoxy-2H-1,3-benzodioxole-5-carboxylate

Chemical Property:

PSA：80.01000
LogP:1.37390
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:225.06372245
Heavy Atom Count:16
Complexity:272

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=CC2=C1OCO2)C(=O)OC)N

Technology Process of Methyl 6-amino-7-methoxy-2H-1,3-benzodioxole-5-carboxylate

There total 11 articles about Methyl 6-amino-7-methoxy-2H-1,3-benzodioxole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 15794-51-1
methyl 7-methoxy-6-nitro-1,3-benzodioxole-5-carboxylate

: 109893-05-2
methyl 6-amino-7-methoxy-1,3-benzodioxole-5-carboxylate

Guidance literature:: With hydrogenchloride; tin(ll) chloride; for 0.5h; Heating;
DOI:10.1002/hlca.200390180

Reference yield:

: 99-24-1
methyl galloate

: 109893-05-2
methyl 6-amino-7-methoxy-1,3-benzodioxole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: Na₂B₄O₇; H₂SO₄

2: K₂CO₃ / acetone

3: 77 percent / HNO₃ / 2 h / 0 - 5 °C

4: 34 percent / SnCl₂*2H₂O; aq. HCl / 0.5 h / Heating

With hydrogenchloride; borax; sulfuric acid; nitric acid; potassium carbonate; tin(ll) chloride; In acetone;
DOI:10.1016/j.bmcl.2004.02.055

Reference yield:

: 22934-58-3
methyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate

: 109893-05-2
methyl 6-amino-7-methoxy-1,3-benzodioxole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / HNO₃ / 2 h / 0 - 5 °C

2: 34 percent / SnCl₂*2H₂O; aq. HCl / 0.5 h / Heating

With hydrogenchloride; nitric acid; tin(ll) chloride;
DOI:10.1016/j.bmcl.2004.02.055