Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-1-oxo-6-(phenylmethoxy)- 2-(phenylmethyl)-7-isoquinolinyl ester

Base Information

Chemical Name:Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-1-oxo-6-(phenylmethoxy)- 2-(phenylmethyl)-7-isoquinolinyl ester
CAS No.:109961-03-7
Molecular Formula:C32H41NO5
Molecular Weight:519.681
Hs Code.:
Mol file:109961-03-7.mol

Synonyms:

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Chemical Property of Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-1-oxo-6-(phenylmethoxy)- 2-(phenylmethyl)-7-isoquinolinyl ester

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Technology Process of Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-1-oxo-6-(phenylmethoxy)- 2-(phenylmethyl)-7-isoquinolinyl ester

There total 6 articles about Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-1-oxo-6-(phenylmethoxy)- 2-(phenylmethyl)-7-isoquinolinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 102673-37-0
(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-6-(benzyloxy)-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-5-((methoxymethoxy)methyl)-1(2H)-isoquinolone

: 109961-03-7
(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-6-(benzyloxy)-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-5-(hydroxymethyl)-1(2H)-isoquinolone

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 40 ℃; for 30h;
DOI:10.1016/S0040-4039(00)95001-9

Reference yield:

: 96648-91-8
(4aR^*,5S^*,6S^*,7R^*)-2-benzyl-3,4,4a,5,6,7-hexahydro-5-((methoxymethoxy)methyl)-6,7-oxy-1(2H)-isoquinolone

: 109961-03-7
(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-6-(benzyloxy)-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-5-(hydroxymethyl)-1(2H)-isoquinolone

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / lithium 2-ethylhexanoate / 1,2-dimethoxy-ethane / 16 h / Heating

2: 76 percent / Ag₂O, CaSO₄ / 84 h / 50 °C

3: 86 percent / p-toluenesulfonic acid / methanol / 30 h / 40 °C

With calcium sulfate; lithium 2-ethylhexanoate; toluene-4-sulfonic acid; silver(l) oxide; In methanol; 1,2-dimethoxyethane;
DOI:10.1021/ja00254a036

Reference yield:

: 96648-92-9
(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-6-hydroxy-5-((methoxymethoxy)methyl)-1(2H)-isoquinolone

: 109961-03-7
(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-6-(benzyloxy)-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-5-(hydroxymethyl)-1(2H)-isoquinolone

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / Ag₂O, CaSO₄ / 84 h / 50 °C

2: 86 percent / p-toluenesulfonic acid / methanol / 30 h / 40 °C

With calcium sulfate; toluene-4-sulfonic acid; silver(l) oxide; In methanol;
DOI:10.1021/ja00254a036