Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-6-methoxy-1-oxo-2-(phen ylmethyl)-7-isoquinolinyl ester

Base Information

Chemical Name:Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-6-methoxy-1-oxo-2-(phen ylmethyl)-7-isoquinolinyl ester
CAS No.:109961-05-9
Molecular Formula:C26H37NO5
Molecular Weight:443.583
Hs Code.:
Mol file:109961-05-9.mol

Synonyms:

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Chemical Property of Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-6-methoxy-1-oxo-2-(phen ylmethyl)-7-isoquinolinyl ester

Chemical Property:

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Technology Process of Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-6-methoxy-1-oxo-2-(phen ylmethyl)-7-isoquinolinyl ester

There total 4 articles about Hexanoic acid, 2-ethyl-, 1,2,3,4,4a,5,6,7-octahydro-5-(hydroxymethyl)-6-methoxy-1-oxo-2-(phen ylmethyl)-7-isoquinolinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96648-92-9
(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-6-hydroxy-5-((methoxymethoxy)methyl)-1(2H)-isoquinolone

: 109961-05-9
2-Ethyl-hexanoic acid (4aR,5R,6R,7R)-2-benzyl-5-hydroxymethyl-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinolin-7-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

2: acid / methanol

With calcium sulfate; silver(l) oxide; acid; In methanol;
DOI:10.1021/ja00254a036

Reference yield:

: 96648-91-8
(4aR^*,5S^*,6S^*,7R^*)-2-benzyl-3,4,4a,5,6,7-hexahydro-5-((methoxymethoxy)methyl)-6,7-oxy-1(2H)-isoquinolone

: 109961-05-9
2-Ethyl-hexanoic acid (4aR,5R,6R,7R)-2-benzyl-5-hydroxymethyl-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinolin-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / lithium 2-ethylhexanoate / 1,2-dimethoxy-ethane / 16 h / Heating

2: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

3: acid / methanol

With calcium sulfate; lithium 2-ethylhexanoate; silver(l) oxide; acid; In methanol; 1,2-dimethoxyethane;
DOI:10.1021/ja00254a036

Reference yield:

: 96648-90-7,109961-10-6
(4aR^*,5S^*)-2-benzyl-5-((methoxymethoxy)methyl)-3,4,4a,5-tetrahydro-1(2H)-isoquinolone

: 109961-05-9
2-Ethyl-hexanoic acid (4aR,5R,6R,7R)-2-benzyl-5-hydroxymethyl-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinolin-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 14 h / 0 °C

2: 90 percent / lithium 2-ethylhexanoate / 1,2-dimethoxy-ethane / 16 h / Heating

3: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

4: acid / methanol

With calcium sulfate; lithium 2-ethylhexanoate; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; acid; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/ja00254a036