L-Glutamic acid, N-[4-[2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido[2,3-d]pyrimidin-6-yl) ethenyl]benzoyl]-, dimethyl ester

Base Information

Chemical Name:L-Glutamic acid, N-[4-[2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido[2,3-d]pyrimidin-6-yl) ethenyl]benzoyl]-, dimethyl ester
CAS No.:110202-62-5
Molecular Formula:C24H25N5O6
Molecular Weight:479.492
Hs Code.:
Mol file:110202-62-5.mol

Synonyms:

Suppliers and Price of L-Glutamic acid, N-[4-[2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido[2,3-d]pyrimidin-6-yl) ethenyl]benzoyl]-, dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of L-Glutamic acid, N-[4-[2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido[2,3-d]pyrimidin-6-yl) ethenyl]benzoyl]-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of L-Glutamic acid, N-[4-[2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido[2,3-d]pyrimidin-6-yl) ethenyl]benzoyl]-, dimethyl ester

There total 4 articles about L-Glutamic acid, N-[4-[2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido[2,3-d]pyrimidin-6-yl) ethenyl]benzoyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253-46-9
4-methoxycarbonylbenzyltriphenylphosphonium bromide

: 110202-62-5
dimethyl N-<4-<2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / NaOMe / dimethylformamide / 168 h / 20 - 25 °C

2: 90 percent / NaOH / 6 h / Heating

3: 1.) Et₃N, (EtO)2POCN / 1.) DMF, 23 deg C to 25 deg C, 30 min, 2.) 20 deg C to 25 deg C, 4 days

With sodium hydroxide; diethyl cyanophosphonate; sodium methylate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00119a018

Reference yield:

: 101810-74-6
2,4-diamino-5-methylpyrido<2,3-d>pyrimidine-6-carboxaldehyde

: 110202-62-5
dimethyl N-<4-<2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / NaOMe / dimethylformamide / 168 h / 20 - 25 °C

2: 90 percent / NaOH / 6 h / Heating

3: 1.) Et₃N, (EtO)2POCN / 1.) DMF, 23 deg C to 25 deg C, 30 min, 2.) 20 deg C to 25 deg C, 4 days

With sodium hydroxide; diethyl cyanophosphonate; sodium methylate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00119a018

Reference yield:

: 110202-57-8
methyl 4-<2-(2,4-diamino-5-methylpyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoate

: 110202-62-5
dimethyl N-<4-<2-(2-amino-1,4-dihydro-5-methyl-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / NaOH / 6 h / Heating

2: 1.) Et₃N, (EtO)2POCN / 1.) DMF, 23 deg C to 25 deg C, 30 min, 2.) 20 deg C to 25 deg C, 4 days

With sodium hydroxide; diethyl cyanophosphonate; triethylamine;
DOI:10.1021/jm00119a018