4-Amino-1-phenyl-2(1H)-quinolinone

Base Information

• Chemical Name: 4-Amino-1-phenyl-2(1H)-quinolinone
• CAS No.: 110216-81-4
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• DSSTox Substance ID: DTXSID601298113
• Mol file: 110216-81-4.mol

Synonyms:DTXSID601298113;4-Amino- 1-phenyl-2(1H)-chinolon;4-Amino-1-phenyl-2(1H)-quinolinone;110216-81-4

Chemical Property of 4-Amino-1-phenyl-2(1H)-quinolinone

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 236.094963011
• Heavy Atom Count: 18
• Complexity: 358

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C3=CC=CC=C3C(=CC2=O)N

Technology Process of 4-Amino-1-phenyl-2(1H)-quinolinone

There total 2 articles about 4-Amino-1-phenyl-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-Benzylamino-1-phenyl-2(1H)-chinolon (110229-47-5) → 4-Amino-1-phenyl-2(1H)-chinolon (110216-81-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 6h;

DOI:10.1007/BF00810876

Reference yield:

4-hydroxy-1-phenylquinolin-2(1H)-one (14994-75-3) → 4-Amino-1-phenyl-2(1H)-chinolon (110216-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 12 h / Heating

2: 66 percent / H₂ / 10percent Pd/C / acetic acid / 6 h

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1007/BF00810876

Reference yield:

4-Amino-1-phenyl-2(1H)-chinolon (110216-81-4) → 4-Azido-1-phenyl-2(1H)-chinolon (110216-62-1)

Guidance literature:

With sodium azide; sodium nitrite; Yield given. Multistep reaction; 1.) acetic acid/H₂₀, 0 - 5 deg C, 15 min; 2.) 3 h;

DOI:10.1007/BF00810876

upstream raw materials:

4-Benzylamino-1-phenyl-2(1H)-chinolon

4-hydroxy-1-phenylquinolin-2(1H)-one

Downstream raw materials:

4-Azido-1-phenyl-2(1H)-chinolon