(+)-[(R)-1-Bromoethyl]benzene

Base Information

• Chemical Name: (+)-[(R)-1-Bromoethyl]benzene
• CAS No.: 1459-14-9
• Molecular Formula: C8H9 Br
• Molecular Weight: 185.063
• Mol file: 1459-14-9.mol

Synonyms:Benzene,(1-bromoethyl)-, (R)-; (+)-(R)-1-Bromo-1-phenylethane;(+)-1-Bromo-1-phenylethane; (R)-(1-Bromoethyl)benzene; (R)-a-Phenethyl bromide; (R)-a-Phenylethyl bromide

Chemical Property of (+)-[(R)-1-Bromoethyl]benzene

Chemical Property:

• Melting Point: -20.49°C (estimate)
• Refractive Index: 1.5612
• Boiling Point: 203.05°C
• PSA: 0.00000
• Density: 1.3108
• LogP: 3.14250

Purity/Quality:

98.5% ^*data from raw suppliers

(R)-(1-Bromoethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+)-[(R)-1-Bromoethyl]benzene

There total 14 articles about (+)-[(R)-1-Bromoethyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-1-phenylethanol (1445-91-6) → (R)-(1-bromoethyl)benzene (1459-14-9)

Guidance literature:

With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.15h;

DOI:10.3906/kim-1804-41

Reference yield: 91.0%

(-)-α-phenethyl alcohol (98-85-1,1445-91-6,1517-69-7,13323-81-4) → (+)-1-phenylbromoethane (585-71-7,1459-14-9,3756-40-9,38661-81-3)

Guidance literature:

With hydrogen bromide; In benzene; at 0 ℃; for 0.166667h; other solvent: toluene;

Reference yield: 60.0%

(1-bromoethyl)benzne (585-71-7,38661-81-3) + (3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione (205517-34-6) → (3R,6S,1'R)-N,N'-bis(p-methoxybenzyl)-6-isopropyl-3-(1'-phenylethyl)piperazine-2,5-dione + (3R,6S,1'S)-N,N'-bis(p-methoxybenzyl)-6-isopropyl-3-(1'-phenylethyl)piperazine-2,5-dione (909299-25-8) + (S)-(-)-α-phenethyl bromide (3756-40-9) + (R)-(1-bromoethyl)benzene (1459-14-9)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tet.2006.05.033

upstream raw materials:

(S)-1-phenylethanol

C₈H₉F₅Si^(2-)*2K⁽¹⁺⁾

(R)-1-phenylethanol

(1-bromoethyl)benzne

Downstream raw materials:

2,3-diphenylbutane

2,3-diphenylbutane

styrene

(1-bromoethyl)benzne

Refernces

• 1、 Essiz, Sel?uk,Da?tan, Arif. "1,2-Dibromotetrachloroethane: An efficient reagent for many transformations by modified Appel reaction". . p. 150 - 156. Retrieved 2019/05/16.
• 2、 Li, Chengxi,Zhang, Yuanyuan,Sun, Qi,Gu, Tongnian,Peng, Henian,Tang, Wenjun. "Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles". supporting information. p. 10774 - 10777. Retrieved 2016/09/09.