9-Amino-N-(2-(dimethylamino)ethyl)-6-methoxy-4-acridinecarboxamide

Base Information

• Chemical Name: 9-Amino-N-(2-(dimethylamino)ethyl)-6-methoxy-4-acridinecarboxamide
• CAS No.: 89459-57-4
• Molecular Formula: C₁₉H₂₂N₄O₂
• Molecular Weight: 338.409
• DSSTox Substance ID: DTXSID10237744
• Wikidata: Q83119956
• ChEMBL ID: CHEMBL358308
• Mol file: 89459-57-4.mol

Synonyms:9-Amino-N-(2-(dimethylamino)ethyl)-6-methoxy-4-acridinecarboxamide;89459-57-4;4-Acridinecarboxamide, 9-amino-N-(2-(dimethylamino)ethyl)-6-methoxy-;CHEMBL358308;DTXSID10237744

Chemical Property of 9-Amino-N-(2-(dimethylamino)ethyl)-6-methoxy-4-acridinecarboxamide

Chemical Property:

• Vapor Pressure: 2.14E-15mmHg at 25°C
• Boiling Point: 622.1°C at 760 mmHg
• Flash Point: 330°C
• Density: 1.233g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 338.17427596
• Heavy Atom Count: 25
• Complexity: 459

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCNC(=O)C1=CC=CC2=C(C3=C(C=C(C=C3)OC)N=C21)N

Technology Process of 9-Amino-N-(2-(dimethylamino)ethyl)-6-methoxy-4-acridinecarboxamide

There total 3 articles about 9-Amino-N-(2-(dimethylamino)ethyl)-6-methoxy-4-acridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-Chloro-6-methoxy-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide → 9-Amino-6-methoxy-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide (89459-57-4)

Guidance literature:

With ammonia; In various solvent(s); at 110 - 120 ℃; for 0.25h;

DOI:10.1021/jm00154a008

Reference yield:

3-methoxy-5-carboxy-9(10H)-acridanone (86611-40-7) → 9-Amino-6-methoxy-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide (89459-57-4)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 1 h / Heating

2: CH₂Cl₂ / 0.5 h / 20 °C

3: NH₃(g) / various solvent(s) / 0.25 h / 110 - 120 °C

With thionyl chloride; ammonia; In dichloromethane;

DOI:10.1021/jm00154a008

Reference yield:

9-Chloro-6-methoxy-acridine-4-carbonyl chloride → 9-Amino-6-methoxy-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide (89459-57-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.5 h / 20 °C

2: NH₃(g) / various solvent(s) / 0.25 h / 110 - 120 °C

With ammonia; In dichloromethane;

DOI:10.1021/jm00154a008

upstream raw materials:

3-methoxy-5-carboxy-9(10H)-acridanone