2-((4-Chloro-6-methoxypyrimidin-2-yl)oxy)benzoic acid

Base Information

Chemical Name:2-((4-Chloro-6-methoxypyrimidin-2-yl)oxy)benzoic acid
CAS No.:110284-77-0
Molecular Formula:C12H9ClN2O4
Molecular Weight:280.667
Hs Code.:
DSSTox Substance ID:DTXSID20558412
Nikkaji Number:J579.365C
Wikidata:Q82440706

Synonyms:110284-77-0;2-((4-Chloro-6-methoxypyrimidin-2-yl)oxy)benzoic acid;2-[(4-Chloro-6-methoxypyrimidin-2-yl)oxy]benzoic acid;SCHEMBL10366685;DTXSID20558412

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((4-Chloro-6-methoxypyrimidin-2-yl)oxy)benzoic acid

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:280.0250845
Heavy Atom Count:19
Complexity:318

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=NC(=N1)OC2=CC=CC=C2C(=O)O)Cl

Technology Process of 2-((4-Chloro-6-methoxypyrimidin-2-yl)oxy)benzoic acid

There total 4 articles about 2-((4-Chloro-6-methoxypyrimidin-2-yl)oxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110284-80-5
Methyl O-(4-chloro-6-methoxypyrimidin-2-yl)salicylate

: 110284-77-0
2-(4'-chloro-6'-methoxypyrimidine-2'-yl)oxy benzoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃;
DOI:10.1002/(SICI)1096-9063(199606)47:2<115::AID-PS397>3.0.CO;2-R

Reference yield:

: 2-Benzylthio-4-chloro-6-methoxypyrimidine

: 110284-77-0
2-(4'-chloro-6'-methoxypyrimidine-2'-yl)oxy benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95.8 percent / oxone / H₂O / 3 h / 20 °C

2: 93.2 percent / NaH / benzene / 3 h / Heating

3: aq. NaOH / methanol / 20 °C

With Oxone; sodium hydroxide; sodium hydride; In methanol; water; benzene; 1: Oxidation / 2: Substitution / 3: Hydrolysis;
DOI:10.1002/(SICI)1096-9063(199606)47:2<115::AID-PS397>3.0.CO;2-R

Reference yield:

: 116040-08-5
4-Chloro-6-methoxy-2-benzylsulfonylpyrimidine

: 110284-77-0
2-(4'-chloro-6'-methoxypyrimidine-2'-yl)oxy benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 93.2 percent / NaH / benzene / 3 h / Heating

2: aq. NaOH / methanol / 20 °C

With sodium hydroxide; sodium hydride; In methanol; benzene; 1: Substitution / 2: Hydrolysis;
DOI:10.1002/(SICI)1096-9063(199606)47:2<115::AID-PS397>3.0.CO;2-R