Glycine, N-[1-[1-[5-oxo-1-[(phenylmethoxy)carbonyl]-L-prolyl]-L-prolyl]-L-prolyl]-, 2-[(1,1-dimethylethoxy)carbonyl]hydrazide

Base Information

Chemical Name:Glycine, N-[1-[1-[5-oxo-1-[(phenylmethoxy)carbonyl]-L-prolyl]-L-prolyl]-L-prolyl]-, 2-[(1,1-dimethylethoxy)carbonyl]hydrazide
CAS No.:110338-26-6
Molecular Formula:C30H40N6O9
Molecular Weight:628.682
Hs Code.:
Mol file:110338-26-6.mol

Synonyms:

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Chemical Property of Glycine, N-[1-[1-[5-oxo-1-[(phenylmethoxy)carbonyl]-L-prolyl]-L-prolyl]-L-prolyl]-, 2-[(1,1-dimethylethoxy)carbonyl]hydrazide

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Technology Process of Glycine, N-[1-[1-[5-oxo-1-[(phenylmethoxy)carbonyl]-L-prolyl]-L-prolyl]-L-prolyl]-, 2-[(1,1-dimethylethoxy)carbonyl]hydrazide

There total 1 articles about Glycine, N-[1-[1-[5-oxo-1-[(phenylmethoxy)carbonyl]-L-prolyl]-L-prolyl]-L-prolyl]-, 2-[(1,1-dimethylethoxy)carbonyl]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.6%

: 53331-45-6
H-Pro-GlyNHNHBoc

: 2131-10-4
Z-pGlu-Pro-OH

: 110338-26-6
Z-pGlu-Pro-Pro-Gly-NHNH-Boc

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; at 4 ℃; for 40h;
DOI:10.1248/cpb.35.2327

Reference yield:

: 110338-26-6
Z-pGlu-Pro-Pro-Gly-NHNH-Boc

: pGlu-Pro-Pro-Gly-Gly-Ser-Lys-Val-Ile-Leu-OH_.CH₃COOH

Guidance literature:: Multi-step reaction with 3 steps

1: 0.75 h / 20 °C

2: isoamyl nitrile, 6N HCl / dimethylformamide; dioxane / -15 deg C, to 10 deg C, 2 min

3: 45 percent / TEA / dimethylformamide; dimethylsulfoxide / 20 h / 4 °C

With hydrogenchloride; Isovaleronitrile; TEA; In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2327

Reference yield:

: 110338-26-6
Z-pGlu-Pro-Pro-Gly-NHNH-Boc

: 110359-92-7
(S)-2-{(S)-2-[(S)-2-(Azidocarbonylmethyl-carbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carbonyl}-5-oxo-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 0.75 h / 20 °C

2: isoamyl nitrile, 6N HCl / dimethylformamide; dioxane / -15 deg C, to 10 deg C, 2 min

With hydrogenchloride; Isovaleronitrile; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.2327