Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-1,4-dihydro-4-oxo-6-pteridinyl ]ethyl]-

Base Information

Chemical Name:Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-1,4-dihydro-4-oxo-6-pteridinyl ]ethyl]-
CAS No.:111323-82-1
Molecular Formula:C20H21N5O4
Molecular Weight:395.418
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-1,4-dihydro-4-oxo-6-pteridinyl ]ethyl]-

Chemical Property:

Purity/Quality:

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Technology Process of Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-1,4-dihydro-4-oxo-6-pteridinyl ]ethyl]-

There total 8 articles about Benzoic acid, 4-[2-[2-[(2,2-dimethyl-1-oxopropyl)amino]-1,4-dihydro-4-oxo-6-pteridinyl ]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 111292-02-5
tert-butyl 4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethyl>benzoate

: 111323-82-1
4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethyl>benzoic acid

Guidance literature:: With hydrogenchloride; In nitromethane; at 0 - 20 ℃; for 0.75h;
DOI:10.1021/jo00236a009

Reference yield:

: 59247-47-1
tert-butyl-4-bromobenzoate

: 111323-82-1
4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethyl>benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine, palladium acetate, triethylamine / 12 h / 100 °C

2: potassium carbonate / methanol / 3 h / Ambient temperature

3: 54 percent / palladium acetate, tri-o-tolylphosphine, copper(I) iodide, triethylamine / acetonitrile / 16 h / 100 °C

4: H₂ / 10percent Pd/C / CH₂Cl₂; methanol / 0.75 h / Ambient temperature

5: O₂ / methanol; CH₂Cl₂ / 72 h / Ambient temperature

6: 83 percent / HCl gas / nitromethane / 0.75 h / 0 - 20 °C

With hydrogenchloride; copper(l) iodide; hydrogen; oxygen; palladium diacetate; potassium carbonate; triethylamine; triphenylphosphine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In methanol; nitromethane; dichloromethane; acetonitrile;
DOI:10.1021/jo00236a009

Reference yield:

: 111291-97-5
4-ethynylbenzoic acid tert-butyl ester

: 111323-82-1
4-<<2-(pivaloylamino)-4(3H)-oxopteridin-6-yl>ethyl>benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 54 percent / palladium acetate, tri-o-tolylphosphine, copper(I) iodide, triethylamine / acetonitrile / 16 h / 100 °C

2: H₂ / 10percent Pd/C / CH₂Cl₂; methanol / 0.75 h / Ambient temperature

3: O₂ / methanol; CH₂Cl₂ / 72 h / Ambient temperature

4: 83 percent / HCl gas / nitromethane / 0.75 h / 0 - 20 °C

With hydrogenchloride; copper(l) iodide; hydrogen; oxygen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In methanol; nitromethane; dichloromethane; acetonitrile;
DOI:10.1021/jo00236a009