N,15-epi(methano(imino))rifamycin SV

Base Information

• Chemical Name: N,15-epi(methano(imino))rifamycin SV
• CAS No.: 62921-34-0
• Molecular Formula: C₃₈H₄₈N₂O₁₁
• Molecular Weight: 708.806
• NSC Number: 262188
• Mol file: 62921-34-0.mol

Synonyms:NSC262188;62921-34-0;N,15-epi(methano(imino))rifamycin SV;NSC-262188

Chemical Property of N,15-epi(methano(imino))rifamycin SV

Chemical Property:

• Vapor Pressure: 1.55E-30mmHg at 25°C
• Boiling Point: 847.5°Cat760mmHg
• Flash Point: 466.3°C
• Density: 1.37g/cm³
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 3
• Exact Mass: 708.32581035
• Heavy Atom Count: 51
• Complexity: 1420

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C=CC=C(C2=NCC3=C(N2)C(=C4C(=C3O)C5=C(C(=C4O)C)OC(C5=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)C
• Isomeric SMILES: CC1/C=C/C=C(\C2=NCC3=C(N2)C(=C4C(=C3O)C5=C(C(=C4O)C)OC(C5=O)(O/C=C/C(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)/C

Technology Process of N,15-epi(methano(imino))rifamycin SV

There total 4 articles about N,15-epi(methano(imino))rifamycin SV which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.9%

N,15-didehydro-15-deoxo-pyrimido-(4,5-b)rifamycin SV → N,15-didehydro-15-deoxo-1',6'-pyrimido-(4,5-b)rifamycin SV (62921-34-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(03)00184-4

Reference yield:

3-formylrifamycin SV (13292-22-3) → N,13-Didehydro-15-deoxo-3,15-epirifamycin sv (62921-34-0)

Guidance literature:

With ammonia; sodium cyanoborohydride; ammonium chloride; In methanol;

DOI:10.1021/jm00220a009

Reference yield:

3-Aminomethyl-rifamycin SV (62921-32-8) → N,13-Didehydro-15-deoxo-3,15-epirifamycin sv (62921-34-0)

Guidance literature:

With acetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)93926-1

upstream raw materials:

3-formylrifamycin SV

3-formylrifamycin SV

3-Aminomethyl-rifamycin SV

Downstream raw materials:

Chinon 4

(1²S,3E,5S,13E,15Z)-7t-acetoxy-1⁵,9c,11t-trihydroxy-5r-methoxy-1^2,4,6t,8c,10c,12t,16-heptamethyl-2-oxa-1(2,8)-furo[2',3':5,6]benzo[1,2-g]quinazolina-cyclohexadecaphane-3,13,15-triene-1^1,6,11-trione