Technology Process of Carbamic acid, [1-[(methoxymethoxy)methyl]-2-(3-oxopropoxy)ethyl]-,
phenylmethyl ester, (S)-
There total 5 articles about Carbamic acid, [1-[(methoxymethoxy)methyl]-2-(3-oxopropoxy)ethyl]-,
phenylmethyl ester, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
for 0.5h;
DOI:10.1021/jm00397a003
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 5 min, room temperature, 2.5 h, 2.) 1 h
2: 82 percent / DIBAH / tetrahydrofuran; hexane / 0.33 h / 0 °C
3: 91 percent / (iPr)2NEt / CH2Cl2 / 1.) 0 deg C, 10 min, 2.) 0 deg C to room temperature
4: 91 percent / 9-BBN / tetrahydrofuran / 1.) 0 deg C to room temperature, 2.) room temperature, 5 h
5: 75 percent / dimethyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.5 h
With
9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00397a003
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / (iPr)2NEt / CH2Cl2 / 1.) 0 deg C, 10 min, 2.) 0 deg C to room temperature
2: 91 percent / 9-BBN / tetrahydrofuran / 1.) 0 deg C to room temperature, 2.) room temperature, 5 h
3: 75 percent / dimethyl sulfoxide, oxalyl chloride / CH2Cl2 / 0.5 h
With
9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00397a003
