L-Proline, 1-[2-[[hydroxy[4-(3-pyridinyl)butyl]phosphinyl]oxy]-1-oxo-6-[[(phenylmeth oxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-

Base Information

Chemical Name:L-Proline, 1-[2-[[hydroxy[4-(3-pyridinyl)butyl]phosphinyl]oxy]-1-oxo-6-[[(phenylmeth oxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-
CAS No.:111496-60-7
Molecular Formula:C₃₅H₄₄N₃O₈P
Molecular Weight:665.723
Hs Code.:
Mol file:111496-60-7.mol

Synonyms:

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Chemical Property of L-Proline, 1-[2-[[hydroxy[4-(3-pyridinyl)butyl]phosphinyl]oxy]-1-oxo-6-[[(phenylmeth oxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-

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Technology Process of L-Proline, 1-[2-[[hydroxy[4-(3-pyridinyl)butyl]phosphinyl]oxy]-1-oxo-6-[[(phenylmeth oxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)-

There total 8 articles about L-Proline, 1-[2-[[hydroxy[4-(3-pyridinyl)butyl]phosphinyl]oxy]-1-oxo-6-[[(phenylmeth oxy)carbonyl]amino]hexyl]-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111497-23-5
(S)-1-[(S)-6-Benzyloxycarbonylamino-2-(4-pyridin-3-yl-butylphosphinoyloxy)-hexanoyl]-pyrrolidine-2-carboxylic acid benzyl ester

: 111496-60-7
1-<(S)-2-<phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

Guidance literature:: With sodium periodate; In 1,4-dioxane; water; Yield given; 1.) room temperature, 18 h, 2.) 55 deg C, 4 h;
DOI:10.1021/jm00396a033

Reference yield:

: 71532-24-6
4-(3-pyridyl)-1-butene

: 111496-60-7
1-<(S)-2-<phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / sodium hypophosphite hydrate, di-tert-butyl peroxide / methanol / 26 h / Heating

2: pyridine hydrochloride, DCC, DMAP / pyridine / 2 h / Ambient temperature

3: NaIO₄ / dioxane; H₂O / 1.) room temperature, 18 h, 2.) 55 deg C, 4 h

With dmap; sodium periodate; sodium hypophosphite; di-tert-butyl peroxide; pyridine hydrochloride; dicyclohexyl-carbodiimide; In 1,4-dioxane; pyridine; methanol; water;
DOI:10.1021/jm00396a033

Reference yield:

: 42491-84-9
(S)-6-Amino-2-hydroxyhexanoic acid

: 111496-60-7
1-<(S)-2-<phosphinyl>oxy>-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / aq. NaOH / 45 h / 0 °C / pH 10

2: 94 percent / Et₃N, hydroxybenzotriazole, DCC / tetrahydrofuran / 1.) 0 deg C_. 3 h, 2.) room temperature, 1 h

3: pyridine hydrochloride, DCC, DMAP / pyridine / 2 h / Ambient temperature

4: NaIO₄ / dioxane; H₂O / 1.) room temperature, 18 h, 2.) 55 deg C, 4 h

With dmap; sodium hydroxide; sodium periodate; pyridine hydrochloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; pyridine; water;
DOI:10.1021/jm00396a033