L-Proline, 1-[N-[N-(N-glycyl-L-valyl)glycyl]-L-leucyl]-, 4-nitrophenyl ester, mono(trifluoroacetate)

Base Information

Chemical Name:L-Proline, 1-[N-[N-(N-glycyl-L-valyl)glycyl]-L-leucyl]-, 4-nitrophenyl ester, mono(trifluoroacetate)
CAS No.:111583-48-3
Molecular Formula:C₃₁H₄₆N₆O₁₀
Molecular Weight:662.74
Hs Code.:
Mol file:111583-48-3.mol

Synonyms:

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Chemical Property of L-Proline, 1-[N-[N-(N-glycyl-L-valyl)glycyl]-L-leucyl]-, 4-nitrophenyl ester, mono(trifluoroacetate)

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Technology Process of L-Proline, 1-[N-[N-(N-glycyl-L-valyl)glycyl]-L-leucyl]-, 4-nitrophenyl ester, mono(trifluoroacetate)

There total 4 articles about L-Proline, 1-[N-[N-(N-glycyl-L-valyl)glycyl]-L-leucyl]-, 4-nitrophenyl ester, mono(trifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 5070-13-3
bis-(p-nitrophenyl) carbonate

: 111583-45-0
Boc-Gly-Val-Gly-Leu-Pro-OH

: 111583-48-3
Boc-Gly-Val-Gly-Leu-Pro-ONp

Guidance literature:: With pyridine;
DOI:10.1021/j100313a053

Reference yield:

: 83610-64-4
leucylproline benzyl ester

: 111583-48-3
Boc-Gly-Val-Gly-Leu-Pro-ONp

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 1-hydroxybenzotriazole, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide, N-methylmorpholine / dimethylformamide / Ambient temperature

2: 83.3 percent / 10percent Pd/C / acetic acid

3: 77 percent / pyridine

With 4-methyl-morpholine; pyridine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/j100313a053

Reference yield:

: 96847-92-6
N-t-butoxycarbonylglycyl-L-valylglycine

: 111583-48-3
Boc-Gly-Val-Gly-Leu-Pro-ONp

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 1-hydroxybenzotriazole, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide, N-methylmorpholine / dimethylformamide / Ambient temperature

2: 83.3 percent / 10percent Pd/C / acetic acid

3: 77 percent / pyridine

With 4-methyl-morpholine; pyridine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/j100313a053