N-Acetyliodocolchinol

Base Information

• Chemical Name: N-Acetyliodocolchinol
• CAS No.: 38838-27-6
• Molecular Formula: C20H22INO5
• Molecular Weight: 483.303
• Mol file: 38838-27-6.mol

Synonyms:N-Acetyliodocolchinol;Acetamide, N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-5H-dibenzo(a,c)cyclohepten-5-yl)-, (S)-;38838-27-6;NSC 33408;N-Acetyl-10-iodocolchinol;NTJNSPIBKNYJBX-UHFFFAOYSA-N;N-(3-Hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-5-yl)acetamide #

Chemical Property of N-Acetyliodocolchinol

Chemical Property:

• Vapor Pressure: 9.36E-16mmHg at 25°C
• Boiling Point: 615.8°C at 760 mmHg
• Flash Point: 326.2°C
• Density: 1.61g/cm³
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 483.05427
• Heavy Atom Count: 27
• Complexity: 521

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC(=C(C=C13)O)I)OC)OC)OC

Technology Process of N-Acetyliodocolchinol

There total 5 articles about N-Acetyliodocolchinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

colchiceine (477-27-0,1990-46-1) → (aR,5S)-N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-5-yl)-acetamide (38838-27-6)

Guidance literature:

With iodine; sodium hydroxide; In water; at 0 - 5 ℃; for 2h;

DOI:10.1021/acs.bioconjchem.9b00051

Reference yield: 93.0%

colchicine (64-86-8,54192-66-4) → (aR,5S)-N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-5-yl)-acetamide (38838-27-6)

Guidance literature:

colchicine; With hydrogenchloride; acetic acid; In water; at 100 ℃; for 3h;

With iodine; potassium iodide; sodium hydroxide; In water; at 0 - 5 ℃; for 1h;

DOI:10.1016/j.ejmech.2020.112724

Reference yield:

→ (aR,5S)-N-(3-hydroxy-2-iodo-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-5-yl)-acetamide (38838-27-6)

Guidance literature:

With sodium hydroxide; iodine; potassium iodide;

upstream raw materials:

colchiceine

colchicine

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