7-Hydroxyfluphenazine

Base Information

• Chemical Name: 7-Hydroxyfluphenazine
• CAS No.: 33098-48-5
• Molecular Formula: C₂₂H₂₆F₃N₃O₂S
• Molecular Weight: 453.529
• DSSTox Substance ID: DTXSID40186756
• Nikkaji Number: J381.159J
• Wikidata: Q83058136
• Mol file: 33098-48-5.mol

Synonyms:7-hydroxyfluphenazine;7-OHFLU

Chemical Property of 7-Hydroxyfluphenazine

Chemical Property:

• Vapor Pressure: 1.22E-16mmHg at 25°C
• Melting Point: 164-166°C
• Boiling Point: 628.1°Cat760mmHg
• PKA: 9.34±0.20(Predicted)
• Flash Point: 333.6°C
• PSA: 75.48000
• Density: 1.324g/cm³
• LogP: 3.95450
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 6
• Exact Mass: 453.16978274
• Heavy Atom Count: 31
• Complexity: 577

Purity/Quality:

98%Min ^*data from raw suppliers

7-Hydroxy fluphenazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCCN2C3=C(C=C(C=C3)O)SC4=C2C=C(C=C4)C(F)(F)F)CCO
• Uses: A metabolite of Fluphenazine (F598400).

Technology Process of 7-Hydroxyfluphenazine

There total 5 articles about 7-Hydroxyfluphenazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-trifluoromethyl-7-hydroxyphenothiazine (20465-15-0) → 7-hydroxyfluphenazine (33098-48-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 34 percent / sodium hydrosulphite/conc. aq. HCl / 1.)r.t., 3 h 2.)80 deg C, 2 h

2: NaH / xylene / 1.)80 deg C, 3 h 2.)reflux, 8 h

3: 10percent aq. HCl

With hydrogenchloride; sodium disulfite; sodium hydride; In xylene;

DOI:10.1002/jhet.5570180807

Reference yield:

2-trifluoromethyl-7-tetrahydropyranyloxyphenothiazine (77437-36-6) → 7-hydroxyfluphenazine (33098-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / xylene / 1.)80 deg C, 3 h 2.)reflux, 8 h

2: 10percent aq. HCl

With hydrogenchloride; sodium hydride; In xylene;

DOI:10.1002/jhet.5570180807

Reference yield:

zinc mercaptide of 2-amino-4-trifluoromethylbenzenethiol (368-75-2) → 7-hydroxyfluphenazine (33098-48-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent

2: 34 percent / sodium hydrosulphite/conc. aq. HCl / 1.)r.t., 3 h 2.)80 deg C, 2 h

3: NaH / xylene / 1.)80 deg C, 3 h 2.)reflux, 8 h

4: 10percent aq. HCl

With hydrogenchloride; sodium disulfite; sodium hydride; In xylene;

DOI:10.1002/jhet.5570180807

upstream raw materials:

2-trifluoromethyl-7-hydroxyphenothiazine

2-trifluoromethyl-7-tetrahydropyranyloxyphenothiazine

zinc mercaptide of 2-amino-4-trifluoromethylbenzenethiol

chloro-p-hydroquinone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 33098-48-5 7-hydroxyfluphenazine

Send

Send

Metric Ton KG G Pound L ML

Send

Send