2-(5-chloro-2-methoxy-N-methylsulfonylanilino)-N-(2-fluorophenyl)acetamide

Base Information

• Chemical Name: 2-(5-chloro-2-methoxy-N-methylsulfonylanilino)-N-(2-fluorophenyl)acetamide
• CAS No.: 6458-65-7
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.189
• DSSTox Substance ID: DTXSID20361802
• Wikidata: Q82144329

Synonyms:6458-65-7;CBKinase1_001620;CBKinase1_014020;DTXSID20361802;STK916544;2-(5-chloro-2-methoxy-N-methylsulfonylanilino)-N-(2-fluorophenyl)acetamide;AKOS003206004;SR-01000235086;SR-01000235086-1;BRD-K81728577-001-01-4;N~2~-(5-chloro-2-methoxyphenyl)-N-(2-fluorophenyl)-N~2~-(methylsulfonyl)glycinamide

Chemical Property of 2-(5-chloro-2-methoxy-N-methylsulfonylanilino)-N-(2-fluorophenyl)acetamide

Chemical Property:

• Density: 1.453g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 386.0503340
• Heavy Atom Count: 25
• Complexity: 557

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Cl)N(CC(=O)NC2=CC=CC=C2F)S(=O)(=O)C

Technology Process of 2-(5-chloro-2-methoxy-N-methylsulfonylanilino)-N-(2-fluorophenyl)acetamide

There total 1 articles about 2-(5-chloro-2-methoxy-N-methylsulfonylanilino)-N-(2-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-acetylamino-benzooxazole-2-sulfonic acid; potassium salt (4694-90-0) → 6-Acetamido-2-aminobenzoxazole (6458-65-7)

Guidance literature:

With ammonium hydroxide; at 60 - 70 ℃; for 1.5h;

DOI:10.1007/BF00480957

Reference yield:

6-Acetamido-2-aminobenzoxazole (6458-65-7) → 4-amino-N-(6-amino-benzooxazol-2-yl)-benzenesulfonamide (6795-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: py

2: aq. NaOH

With pyridine; sodium hydroxide;

DOI:10.1007/BF00742358

Reference yield:

6-Acetamido-2-aminobenzoxazole (6458-65-7) + 4-methoxycarbonylamino-benzenesulfonyl chloride (21926-53-4) → [4-(6-acetylamino-benzooxazol-2-ylsulfamoyl)-phenyl]-carbamic acid methyl ester (6795-12-6)

Guidance literature:

With pyridine;

DOI:10.1007/BF00742358

upstream raw materials:

6-acetylamino-benzooxazole-2-sulfonic acid; potassium salt

Downstream raw materials:

[4-(6-acetylamino-benzooxazol-2-ylsulfamoyl)-phenyl]-carbamic acid methyl ester

4-amino-N-(6-amino-benzooxazol-2-yl)-benzenesulfonamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 6458-65-7 N~2~-(5-chloro-2-methoxyphenyl)-N-(2-fluorophenyl)-N~2~-(methylsulfonyl)glycinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send