L-Glutamic acid, N-[4-[[[2-amino-5-[[(8-ethoxy-8-oxooctyl)amino]thioxomethyl]-1,4,5,6,7,8 -hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-

Base Information

Chemical Name:L-Glutamic acid, N-[4-[[[2-amino-5-[[(8-ethoxy-8-oxooctyl)amino]thioxomethyl]-1,4,5,6,7,8 -hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-
CAS No.:111823-28-0
Molecular Formula:C30H42N8O8S
Molecular Weight:674.778
Hs Code.:
Mol file:111823-28-0.mol

L-Glutamic acid,
N-[4-[[[2-amino-5-[[(8-ethoxy-8-oxooctyl)amino]thioxomethyl]-1,4,5,6,7,8
-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-

Synonyms:

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Chemical Property of L-Glutamic acid, N-[4-[[[2-amino-5-[[(8-ethoxy-8-oxooctyl)amino]thioxomethyl]-1,4,5,6,7,8 -hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-

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Technology Process of L-Glutamic acid, N-[4-[[[2-amino-5-[[(8-ethoxy-8-oxooctyl)amino]thioxomethyl]-1,4,5,6,7,8 -hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-

There total 3 articles about L-Glutamic acid, N-[4-[[[2-amino-5-[[(8-ethoxy-8-oxooctyl)amino]thioxomethyl]-1,4,5,6,7,8 -hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 135-16-0
tetrahydrofolic acid

: 111823-31-5
ethyl 6-isothiocyanatocaprylate

: 111823-28-0
(S)-2-(4-{[2-Amino-5-(7-ethoxycarbonyl-heptylthiocarbamoyl)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid

Guidance literature:: With sodium acetate; In water; for 3h;
DOI:10.1021/jm00398a034

Reference yield:

: 1002-57-9
8-Aminooctanoic acid

: 111823-28-0
(S)-2-(4-{[2-Amino-5-(7-ethoxycarbonyl-heptylthiocarbamoyl)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / SOCl₂ / 18 h / Ambient temperature

2: 65 percent / aq. NaOH / H₂O; CHCl₃

3: 6 percent / NaOAc*3H₂O / H₂O / 3 h

With sodium hydroxide; thionyl chloride; sodium acetate; In chloroform; water;
DOI:10.1021/jm00398a034

Reference yield:

: 29833-31-6
8-aminooctanoic acid ethyl ester hydrochloride

: 111823-28-0
(S)-2-(4-{[2-Amino-5-(7-ethoxycarbonyl-heptylthiocarbamoyl)-4-oxo-3,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / aq. NaOH / H₂O; CHCl₃

2: 6 percent / NaOAc*3H₂O / H₂O / 3 h

With sodium hydroxide; sodium acetate; In chloroform; water;
DOI:10.1021/jm00398a034