(4-Aminophenyl)phosphonic acid

Base Information

• Chemical Name: (4-Aminophenyl)phosphonic acid
• CAS No.: 5337-17-7
• Molecular Formula: C6H8 N O3 P
• Molecular Weight: 173.108
• European Community (EC) Number: 226-260-7
• NSC Number: 55744,417
• UNII: 5WCV1BQ6M2
• DSSTox Substance ID: DTXSID20201532
• Nikkaji Number: J217.900H
• Wikidata: Q48937962
• Mol file: 5337-17-7.mol

Synonyms:4-aminobenzenephosphonic acid;4-aminophenylphosphonic acid;p-aminophenylphosphonic acid;phosphanilic acid;phosphanilic acid, potassium salt;potassium phosphanilate

Chemical Property of (4-Aminophenyl)phosphonic acid

Chemical Property:

• Vapor Pressure: 1.44E-08mmHg at 25°C
• Melting Point: 245°C(lit.)
• Boiling Point: 441.4°Cat760mmHg
• PKA: pK3: 7.53 (25°C)
• Flash Point: 220.7°C
• PSA: 93.36000
• Density: 1.51g/cm³
• LogP: 0.65300
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 173.02418011
• Heavy Atom Count: 11
• Complexity: 171

Purity/Quality:

97% ^*data from raw suppliers

(4-Aminophenyl)phosphonic Acid >98.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)P(=O)(O)O

Technology Process of (4-Aminophenyl)phosphonic acid

There total 10 articles about (4-Aminophenyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethyl (4-aminophenyl)phosphonate (42822-57-1) → 4-aminophenylphosphonic acid (5337-17-7)

Guidance literature:

With hydrogenchloride; In water; for 12h; Heating;

Reference yield: 62.0%

4-acetylaminophenylphosphonic acid diethyl ester (62956-32-5) → 4-aminophenylphosphonic acid (5337-17-7)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1039/b518260c

Reference yield:

4-chlorophenylphosphonic acid (5431-35-6) → 4-aminophenylphosphonic acid (5337-17-7)

Guidance literature:

With ammonia; copper; at 150 ℃;

DOI:10.1021/ja01853a032

upstream raw materials:

4-nitropheylphosphonic acid

4-chlorophenylphosphonic acid

4-bromophenylphosphonic acid

diethyl (4-aminophenyl)phosphonate

Downstream raw materials:

(4-acetylamino-phenyl)-phosphonic acid

4-hydroxybenzenephosphonic acid

(4-iodo-phenyl)-phosphonic acid

(4-amino-cyclohexyl)-phosphonic acid