L-(1-~14~C)leucine

Base Information

• Chemical Name: L-(1-~14~C)leucine
• CAS No.: 36724-65-9
• Molecular Formula: C6H13NO2
• Molecular Weight: 133.1655
• Mol file: 36724-65-9.mol

Synonyms:

Chemical Property of L-(1-~14~C)leucine

Chemical Property:

• Density: 1.035g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-(1-~14~C)leucine

There total 5 articles about L-(1-~14~C)leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-acetyl-[1-14C]-leucine (1403762-02-6) → D-[1-14C]-leucine (26011-27-8,36724-65-9)

Guidance literature:

N-acetyl-[1-¹⁴C]-leucine; With D-aminoacylase; sodium hydrogencarbonate; at 37 ℃; for 72h;

With hydrogenchloride; In water;

DOI:10.1002/jlcr.2958

Reference yield:

potassium [14C]cyanide + 1-hydroxy-3-methylbutane-1-sulfonate sodium salt (42849-44-5) → C5(14)CH13NO2 (997-33-1,36724-65-9)

Guidance literature:

potassium [14C]cyanide; 1-hydroxy-3-methylbutane-1-sulfonate sodium salt; In water; for 4h; Inert atmosphere;

With ammonia; In ethanol; Inert atmosphere;

With hydrogen bromide; at 110 ℃; for 1h; Inert atmosphere;

DOI:10.1002/jlcr.2958

Reference yield:

isovaleraldehyde (590-86-3) → D-[1-14C]-leucine (26011-27-8,36724-65-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium metabisulfite / water / 0.5 h / 50 °C / Inert atmosphere

2.1: water / 4 h / Inert atmosphere

2.2: Inert atmosphere

2.3: 1 h / 110 °C / Inert atmosphere

3.1: hydrogenchloride / water / Inert atmosphere

4.1: D-aminoacylase; sodium hydrogencarbonate / 72 h / 37 °C

With hydrogenchloride; sodium metabisulfite; D-aminoacylase; sodium hydrogencarbonate; In water; 2.1: |Strecker Aminoacid Synthesis / 2.2: |Strecker Aminoacid Synthesis / 2.3: |Strecker Aminoacid Synthesis;

DOI:10.1002/jlcr.2958

upstream raw materials:

isovaleraldehyde

N-acetyl-[1-¹⁴C]-leucine

C₅⁽¹⁴⁾CH₁₃NO₂

1-hydroxy-3-methylbutane-1-sulfonate sodium salt

Downstream raw materials:

D-[1-¹⁴C]-leucine

Refernces