Tetradecanoic acid, 3-(phenylmethoxy)-, methyl ester, (S)-

Base Information

Chemical Name:Tetradecanoic acid, 3-(phenylmethoxy)-, methyl ester, (S)-
CAS No.:112031-18-2
Molecular Formula:C22H36O3
Molecular Weight:348.51900
Hs Code.:

Synonyms:(S)-3-Benzyloxy-tetradecanoic acid methyl ester;

Suppliers and Price of Tetradecanoic acid, 3-(phenylmethoxy)-, methyl ester, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Tetradecanoic acid, 3-(phenylmethoxy)-, methyl ester, (S)-

Chemical Property:

Boiling Point:443.5±20.0 °C(Predicted)
PSA：35.53000
Density:0.958±0.06 g/cm3(Predicted)
LogP:6.05580

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (S)-Methyl 3-(Benzyloxy)tetradecanoate is an intermediate for the synthesis of (R,S,S,S)-Orlistat (O686480), which is an isomeric impurity of Orlistat (O686500) with modulatory activity on endocannabinoid 2-arachidonoylglycerol metabolism.

Technology Process of Tetradecanoic acid, 3-(phenylmethoxy)-, methyl ester, (S)-

There total 6 articles about Tetradecanoic acid, 3-(phenylmethoxy)-, methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 76835-67-1
(S)-methyl 3-hydroxymyristate

: 112031-18-2
methyl (S)-3-benzyloxytetradecanoate

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; cyclohexane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetasy.2008.11.012

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 76062-97-0
methyl (R)-3-hydroxytetradecanoate

: 112031-18-2
methyl (S)-3-benzyloxytetradecanoate

: 114264-01-6
methyl (R)-3-(benzyloxy)tetradecanoate

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; cyclohexane; at 10 - 20 ℃; Yield given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)99592-3

Reference yield:

: 28715-21-1,3422-31-9
(R)-3-hydroxytetradecanoic acid

: 112031-18-2
methyl (S)-3-benzyloxytetradecanoate

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / 2 h / Ambient temperature

2: 0.1 eq. triflic acid / CH₂Cl₂; cyclohexane / 10 - 20 °C

With hydrogenchloride; trifluorormethanesulfonic acid; In dichloromethane; cyclohexane;
DOI:10.1016/S0040-4039(00)99592-3