Benzenemethanamine, N-4-hexynyl-

Base Information

• Chemical Name: Benzenemethanamine, N-4-hexynyl-
• CAS No.: 112069-91-7
• Molecular Formula: C13H17N
• Molecular Weight: 187.285
• Mol file: 112069-91-7.mol

Synonyms:

Chemical Property of Benzenemethanamine, N-4-hexynyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanamine, N-4-hexynyl-

There total 3 articles about Benzenemethanamine, N-4-hexynyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonic acid hex-4-ynyl ester (68275-05-8) + benzylamine (100-46-9) → N-benzyl-4-hexyn-1-amine (112069-91-7)

Guidance literature:

With sodium iodide; In dimethyl sulfoxide; at 47 - 53 ℃; for 5h; Inert atmosphere;

DOI:10.15227/orgsyn.070.0111

Reference yield:

4-hexyn-1-ol (928-93-8) → N-benzyl-4-hexyn-1-amine (112069-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / -10 °C / Inert atmosphere

2: sodium iodide / dimethyl sulfoxide / 5 h / 47 - 53 °C / Inert atmosphere

With triethylamine; sodium iodide; In dichloromethane; dimethyl sulfoxide;

DOI:10.15227/orgsyn.070.0111

Reference yield:

1-(tetrahydropyranyloxy)-4-pentyn (62992-46-5) → N-benzyl-4-hexyn-1-amine (112069-91-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

1.2: 2 h / Reflux; Inert atmosphere

2.1: triethylamine / dichloromethane / -10 °C / Inert atmosphere

3.1: sodium iodide / dimethyl sulfoxide / 5 h / 47 - 53 °C / Inert atmosphere

With n-butyllithium; triethylamine; sodium iodide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide;

DOI:10.15227/orgsyn.070.0111

upstream raw materials:

methanesulfonic acid hex-4-ynyl ester

benzylamine

4-hexyn-1-ol

1-(tetrahydropyranyloxy)-4-pentyn

Downstream raw materials:

1-Benzyl-3-[1-iodo-eth-(E)-ylidene]-piperidine-2-carboxylic acid ethyl ester

1-Benzyl-3-eth-(Z)-ylidene-2-methyl-piperidine

1-benzyl-2-methylpiperidin-3-one

5-(4-Methoxy-benzyl)-2-methyl-1,5-diaza-spiro[2.5]oct-1-ene