6-Methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine

Base Information

Chemical Name:6-Methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine
CAS No.:103294-21-9
Molecular Formula:C23H23 N5 O3
Molecular Weight:417.4604
Hs Code.:
DSSTox Substance ID:DTXSID80145766
Nikkaji Number:J494.256F
Wikidata:Q83010382
Mol file:103294-21-9.mol

Synonyms:FK 360;FK-360;FK360

Suppliers and Price of 6-Methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-Methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine

Chemical Property:

Vapor Pressure:4.31E-12mmHg at 25°C
Boiling Point:548.7°C at 760 mmHg
Flash Point:285.7°C
Density:1.262g/cm³
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:417.18008961
Heavy Atom Count:31
Complexity:627

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NC(=N1)C2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)N4CCN(CC4)C

Technology Process of 6-Methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine

There total 12 articles about 6-Methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-01-3
1-methyl-piperazine

: 103293-96-5
6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid

: 103294-21-9
6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 103294-21-9
6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 33.8 percent / acetic acid, piperidine / benzene / 2.5 h / Heating

2: Et₃N / butan-1-ol / 2 h / Heating

3: MnO₂ / CHCl₃ / 1 h / Heating

With piperidine; manganese(IV) oxide; acetic acid; triethylamine; In chloroform; butan-1-ol; benzene;
DOI:10.1248/cpb.40.2423