3-Phenyl-3-pyrrolidinol HCl

Base Information

• Chemical Name: 3-Phenyl-3-pyrrolidinol HCl
• CAS No.: 1488-02-4
• Molecular Formula: C10H13NO
• Molecular Weight: 199.68
• Hs Code.: 2933998090
• Mol file: 1488-02-4.mol

Synonyms:3-Pyrrolidinol,3-phenyl-,hydrochloride;3-Pyrrolidinol,hydrochloride;3-Phenyl-3-pyrrolidinol hydrochloride;3-phenyl-pyrrolidin-3-ol,hydrochloride;3-Phenyl-3-pyrrolidinol HCl;3-phenyl-3-hydroxypyrrolidine hydrochloride;

Chemical Property of 3-Phenyl-3-pyrrolidinol HCl

Chemical Property:

• Vapor Pressure: 0.00156mmHg at 25°C
• Boiling Point: 282.7°C at 760 mmHg
• Flash Point: 122.8°C
• PSA: 32.26000
• LogP: 1.99830

Purity/Quality:

99%, ^*data from raw suppliers

3-Phenyl-3-pyrrolidinol hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenyl-3-pyrrolidinol HCl

There total 1 articles about 3-Phenyl-3-pyrrolidinol HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-hydroxy-3-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester (851000-71-0) → 3-phenylpyrrolidin-3-ol hydrochloride (1488-02-4)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

3-phenylpyrrolidin-3-ol hydrochloride (1488-02-4) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 3-hydroxy-3-phenylpyrrolidine-1-carboxylate

Guidance literature:

With triethylamine; palladium; In tetrahydrofuran;

Reference yield:

3-phenylpyrrolidin-3-ol hydrochloride (1488-02-4) + 5-Benzyl-4-isoxazolecarboxylic acid (134541-07-4) → 1-[(5-benzylisoxazol-4-yl)carbonyl]-3-phenylpyrrolidin-3-ol (1003559-97-4)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

3-hydroxy-3-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

1-[(5-benzylisoxazol-4-yl)carbonyl]-3-phenylpyrrolidin-3-ol