1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE

Base Information

• Chemical Name: 1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE
• CAS No.: 940-76-1
• Molecular Formula: C7H4 F4 S
• Molecular Weight: 196.168
• Hs Code.: 29039990
• Mol file: 940-76-1.mol

Synonyms:Sulfide,p-fluorophenyl trifluoromethyl (6CI,7CI,8CI); p-Fluorophenyl trifluoromethylsulfide

Chemical Property of 1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE

Chemical Property:

• Vapor Pressure: 29.3mmHg at 25°C
• Refractive Index: 1.45
• Boiling Point: 109.3 °C at 760 mmHg
• Flash Point: 19.9 °C
• PSA: 25.30000
• Density: 1.38 g/cm³
• LogP: 3.43760
• Sensitive.: Stench

Purity/Quality:

97% ^*data from raw suppliers

1-Fluoro-4-(trifluoromethylthio)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): TXi
• Hazard Codes: T,Xi
• Statements: 10-36/37/38
• Safety Statements: 23-26-36-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE

There total 22 articles about 1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-Fluorothiophenol (371-42-6) + iodotrifluoromethane (2314-97-8,263005-66-9) → (4-fluorophenyl)(trifluoromethyl)thioether (940-76-1)

Guidance literature:

In ammonia; for 0.5h; Irradiation;

Reference yield: 84.0%

4-Fluorothiophenol (371-42-6) + Langlois reagent (2926-29-6) → (4-fluorophenyl)(trifluoromethyl)thioether (940-76-1)

Guidance literature:

With iodine pentoxide; In dimethyl sulfoxide; at 110 ℃; for 24h;

DOI:10.1039/c5cy01561h

Reference yield: 84.0%

α,α-difluoro(4-fluorophenylthio)acetic acid (911360-86-6) → (4-fluorophenyl)(trifluoromethyl)thioether (940-76-1)

Guidance literature:

With tetrafluoroboric acid; selectfluor II; silver nitrate; In dichloromethane; water; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01779

upstream raw materials:

(4-fluoro-phenyl)-trichloromethyl sulfide

4-Fluorothiophenol

iodotrifluoromethane

bis(4-fluorophenyl)disulfide

Downstream raw materials:

p-fluorophenyl trifluoromethyl sulfone

1-fluoro-4-((trifluoromethyl)sulfinyl)benzene

rhodium hydrido (PEt₃)3 complex

methyl (4-((trifluoromethyl)sulfonyl)phenyl)sulfane