Thiazolo[4,5-b]pyrazin-2-amine

Base Information

• Chemical Name: Thiazolo[4,5-b]pyrazin-2-amine
• CAS No.: 112342-71-9
• Molecular Formula: C5H4N4S
• Molecular Weight: 152.17700
• European Community (EC) Number: 861-607-1
• Mol file: 112342-71-9.mol

Synonyms:Thiazolo[4,5-b]pyrazin-2-amine;112342-71-9;[1,3]thiazolo[4,5-b]pyrazin-2-amine;SCHEMBL2642790;IGXMPTMLSAOJBY-UHFFFAOYSA-N;ZB0362;thiazolo[5,4-b]-pyrazin-2-yl-amine;AKOS022634801;DS-18725;EN300-265015;O12147;F1902-0062

Chemical Property of Thiazolo[4,5-b]pyrazin-2-amine

Chemical Property:

• PSA: 93.66000
• LogP: 0.59860
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 152.01566732
• Heavy Atom Count: 10
• Complexity: 131

Purity/Quality:

NLT 98% ^*data from raw suppliers

Thiazolo[4,5-b]pyrazin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C2C(=N1)N=C(S2)N

Technology Process of Thiazolo[4,5-b]pyrazin-2-amine

There total 2 articles about Thiazolo[4,5-b]pyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-ethoxycarbonylaminothiazolo/4,5-b/pyrazine (112342-69-5) → 2-aminothiazolo/4,5-b/pyrazine (112342-71-9)

Guidance literature:

With water; sodium hydroxide; at 120 ℃; for 16h;

Reference yield:

ethyl[(pyrazin-2-ylamino)carbonothioyl]carbamate (56406-73-6) → 2-aminothiazolo/4,5-b/pyrazine (112342-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / 20percent HCl / 2 h / Heating

2: 54 percent / aq. 50percent NaOH / 5 h / Heating

With hydrogenchloride; sodium hydroxide;

Reference yield: 15.0%

2-aminothiazolo/4,5-b/pyrazine (112342-71-9) → 2-amino-6-bromothiazolo/4,5-b/pyrazine (112342-72-0)

Guidance literature:

With bromine; sodium acetate; acetic acid; for 2h; Ambient temperature;

upstream raw materials:

2-ethoxycarbonylaminothiazolo/4,5-b/pyrazine

ethyl[(pyrazin-2-ylamino)carbonothioyl]carbamate

Downstream raw materials:

2-amino-6-bromothiazolo/4,5-b/pyrazine

Refernces

• 1、 Koren, Bozidar,Stanovnik, Branko,Tisler, Miha. "TRANSFORMATIONS OF 1,2,4-THIADIAZOLO/2,3-x/AZINES". . p. 689 - 697. Retrieved 2007/10/02.