[4-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid

Base Information

Chemical Name:[4-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid
CAS No.:112453-44-8
Molecular Formula:C₁₈H₁₅NO₅
Molecular Weight:325.321
Hs Code.:
DSSTox Substance ID:DTXSID90557311
Wikidata:Q82439171

Synonyms:112453-44-8;2-(4-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)isoxazol-5-yl)acetic acid;DTXSID90557311;[4-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid

Suppliers and Price of [4-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of [4-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:325.09502258
Heavy Atom Count:24
Complexity:416

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NOC(=C2C3=CC=C(C=C3)O)CC(=O)O

Technology Process of [4-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid

There total 8 articles about [4-(4-Hydroxyphenyl)-3-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {3-(4-Methoxy-phenyl)-4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-isoxazol-5-yl}-acetic acid

: 112453-44-8
<4-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-5-isoxazolyl>acetic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; Yield given; Ambient temperature;
DOI:10.1248/cpb.36.3142

Reference yield:

: 13619-63-1
2-(4-hydroxyphenyl)-4-methoxyacetophenone

: 112453-44-8
<4-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-5-isoxazolyl>acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / p-toluenesulfonic acid monohydrate / 6 h / Ambient temperature

2: 70 percent / hydroxylamine hidrochloride, KOH / tetrahydrofuran; ethanol / Ambient temperature

3: n-BuLi / hexane; tetrahydrofuran / 1 h / Ambient temperature

4: concentrated H₂SO₄ / tetrahydrofuran; hexane / 1 h / Heating

5: p-toluenesulfonic acid monohydrate / Ambient temperature

6: n-BuLi / hexane; tetrahydrofuran / 1 h / -70 °C

7: concentrated HCl / tetrahydrofuran / Ambient temperature

With hydrogenchloride; potassium hydroxide; n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; hexane;
DOI:10.1248/cpb.36.3142

Reference yield:

: 120402-03-1
4-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-5-methylisoxazole

: 112453-44-8
<4-(4-hydroxyphenyl)-3-(4-methoxyphenyl)-5-isoxazolyl>acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: p-toluenesulfonic acid monohydrate / Ambient temperature

2: n-BuLi / hexane; tetrahydrofuran / 1 h / -70 °C

3: concentrated HCl / tetrahydrofuran / Ambient temperature

With hydrogenchloride; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane;
DOI:10.1248/cpb.36.3142