Benzenethiol, 2-amino-4,6-bis(1,1-dimethylethyl)-

Base Information

• Chemical Name: Benzenethiol, 2-amino-4,6-bis(1,1-dimethylethyl)-
• CAS No.: 112548-22-8
• Molecular Formula: C14H23NS
• Mol file: 112548-22-8.mol

Synonyms:

Chemical Property of Benzenethiol, 2-amino-4,6-bis(1,1-dimethylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenethiol, 2-amino-4,6-bis(1,1-dimethylethyl)-

There total 4 articles about Benzenethiol, 2-amino-4,6-bis(1,1-dimethylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3,5-di-tert-butylbenzene (22385-77-9) → 2-Mercapto-3,5-di-tbutylanilin (112548-22-8)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; CyJohnPhos / toluene / 1 h / 100 °C / Inert atmosphere; Schlenk technique; Glovebox

2: acetic acid; bromine / 1 h / 20 °C / Schlenk technique

3: potassium hydroxide / 3 h / Inert atmosphere; Schlenk technique; Heating

With bromine; acetic acid; potassium hydroxide; lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; CyJohnPhos; In toluene;

DOI:10.1021/acs.inorgchem.0c03427

Reference yield:

2-Amino-5,7-di-tbutylbenzthiazol (112548-21-7) → 2-Mercapto-3,5-di-tbutylanilin (112548-22-8)

Guidance literature:

With potassium hydroxide; acetic acid; Yield given. Multistep reaction; 1.) 2,3-butandiole, 3 h, 200 degC; 2.) heating;

Reference yield:

3,5-di-tert-butylaniline (2380-36-1) → 2-Mercapto-3,5-di-tbutylanilin (112548-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) glacial CH₃COOH, Br₂, 2.) KOH / 1.) 30 min., RT; 2.) MeOH, H₂O

2: 1.) KOH, 2.) glacial CH₃COOH / 1.) 2,3-butandiole, 3 h, 200 degC; 2.) heating

With potassium hydroxide; bromine; acetic acid;

upstream raw materials:

2-Amino-5,7-di-^tbutylbenzthiazol

3,5-di-tert-butylaniline

3,5-di-tert-butylbenzoic acid

1-bromo-3,5-di-tert-butylbenzene

Downstream raw materials:

1,2-Bis(2-mercapto-3,5-di-^tbutylanilino)ethan