crenulatin

Base Information

• Chemical Name: crenulatin
• CAS No.: 4444-74-0
• Molecular Formula: C11H8 O4
• Molecular Weight: 204.182
• Mol file: 4444-74-0.mol

Synonyms:Coumarin,6-formyl-7-methoxy- (7CI,8CI); Herniarin, 6-formyl- (6CI);6-Formyl-7-methoxycoumarin; 7-Methoxycoumarin-6-aldehyde; Angelical;Crenulatin; Crenulatin (coumarin)

Chemical Property of crenulatin

Chemical Property:

• Vapor Pressure: 1.84E-07mmHg at 25°C
• Boiling Point: 425.9°Cat760mmHg
• Flash Point: 195.2°C
• PSA: 56.51000
• Density: 1.336g/cm³
• LogP: 1.61410

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of crenulatin

There total 11 articles about crenulatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

7-methoxy-6-methylchromen-2-one (53811-57-7) → crenulatin (4444-74-0)

Guidance literature:

With ammonium cerium(IV) nitrate; acetic acid; In diethyl ether; for 0.5h; Heating;

Reference yield: 45.0%

micromelumin → crenulatin (4444-74-0) + propionaldehyde (123-38-6)

Guidance literature:

With oxalic acid; In methanol; Yields of byproduct given; Heating;

Reference yield: 25.0%

Micromelumin (15085-71-9,99528-84-4) → crenulatin (4444-74-0) + 6-(3'-Methyl-3'-chloro-4'-hydroxy-γ-butyrolactonyl)-7-methoxycoumarin (86849-86-7,116589-55-0) + 6-((S)-3-Hydroxy-4-methyl-5-oxo-2,5-dihydro-furan-2-yl)-7-methoxy-chromen-2-one (115071-67-5) + 6-(1'-Carboxy-2'-methyl-3',4'-dihydroxybutenyl)-7-methoxycoumarin (116589-56-1)

Guidance literature:

With pyridine hydrochloride; In pyridine; for 10h; Heating;

upstream raw materials:

suberosin

Micromelumin

7-methoxy-6-methylchromen-2-one

7-hydroxy-6-methylcoumarin

Downstream raw materials:

2,4-dimethoxy-5-methyl-cinnamic acid methyl ester

5-formyl-2,4-dimethoxy-cinnamic acid

Refernces

• 1、 Banerji, J.,Dhara, K. P.,Das, B.,Das, A. K.,Chatterjee, A.. "Studies on Rutaceae: Part VI - Reacrtions and Rearrangements of Coumarins". . p. 21 - 25. Retrieved 2007/10/02.
• 2、 Mock, Joseph R.,Senior, Robert G.,Taylor, Walter C.. "The Chemical Constituents of Australian Zanthoxylum Species. VII. Some Transformation Products of Suberosin". . p. 395 - 411. Retrieved 2007/10/02.