2-hexadecylamino-2,3-bis(hydroxymethyl)norbornene

Base Information

• Chemical Name: 2-hexadecylamino-2,3-bis(hydroxymethyl)norbornene
• CAS No.: 134864-19-0
• Molecular Formula: C₂₅H₄₇NO₂
• Molecular Weight: 393.654
• Mol file: 134864-19-0.mol

Synonyms:Bicyclo[2.2.1]hept-5-ene-2,3-dimethanol,2-(hexadecylamino)-, (2-endo,3-exo)-

Chemical Property of 2-hexadecylamino-2,3-bis(hydroxymethyl)norbornene

Chemical Property:

• Vapor Pressure: 2.25E-13mmHg at 25°C
• Boiling Point: 528.5°Cat760mmHg
• Flash Point: 44.1°C
• PSA: 52.49000
• Density: 0.99g/cm³
• LogP: 5.99370

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hexadecylamino-2,3-bis(hydroxymethyl)norbornene

There total 3 articles about 2-hexadecylamino-2,3-bis(hydroxymethyl)norbornene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,3S,4S)-2-Hexadecylamino-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dimethyl ester (134886-95-6) → 2-endo-hexadecylamino-5-norbornene-2-exo-methanol (134864-19-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.75h; Ambient temperature;

DOI:10.1248/cpb.40.122

Reference yield:

(1R,2S,3S,4S)-2-Amino-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dimethyl ester (140707-30-8) → 2-endo-hexadecylamino-5-norbornene-2-exo-methanol (134864-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / hexamethylphosphoric acid triamide / 4 h / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 0.75 h / Ambient temperature

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1248/cpb.40.122

Reference yield:

hexadecanyl bromide (112-82-3) → 2-endo-hexadecylamino-5-norbornene-2-exo-methanol (134864-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / hexamethylphosphoric acid triamide / 4 h / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 0.75 h / Ambient temperature

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1248/cpb.40.122

upstream raw materials:

(1R,2S,3S,4S)-2-Hexadecylamino-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dimethyl ester

(1R,2S,3S,4S)-2-Amino-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid dimethyl ester

hexadecanyl bromide

Refernces