5'-O-Trityl-2'-deoxyuridine

Base Information

• Chemical Name: 5'-O-Trityl-2'-deoxyuridine
• CAS No.: 14270-73-6
• Molecular Formula: C28H26 N2 O5
• Molecular Weight: 470.525
• Hs Code.: 2934999090
• ChEMBL ID: CHEMBL438428
• DSSTox Substance ID: DTXSID40547404
• Nikkaji Number: J81.741D
• Wikidata: Q82425603
• Mol file: 14270-73-6.mol

Synonyms:5'-O-Trityl-2'-deoxyuridine;14270-73-6;CHEMBL438428;5/'-O-Trityl-2/'-deoxyuridine;1-[(2R,4S,5R)-4-hydroxy-5-(trityloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;1-((2R,4S,5R)-4-Hydroxy-5-((trityloxy)methyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;BDBM50190548;2'-Deoxy-5'-O-trityluridine;2'-deoxy 5'-O-trityluridine;CHEMBL440214;SCHEMBL3576744;5'-O-Trityl-2'-deoxyur-idine;DTXSID40547404;JJJNFNLUKYZAKI-BFLUCZKCSA-N;1-[(2R,4S,5R)-4-hydroxy-5-[(triphenylmethoxy)methyl]oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione;BDBM50173539;MFCD11113892;AKOS015999460;2'-Deoxy-5'-O-(triphenylmethyl)uridine;AC-32248;AS-82109;F87667;A855601;Uridine,2'-deoxy-5'-O-(triphenylmethyl)-(9ci);J-700304;1-(4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione;1-[(2R,4S,5R)-4-hydroxy-5-(trityloxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione;1-((2R,4S,5R)-4-hydroxy-5-(trityloxymethyl)-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;1-((2R,4S,5R)-4-hydroxy-5-(trityloxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Chemical Property of 5'-O-Trityl-2'-deoxyuridine

Chemical Property:

• Melting Point: 204-205 °C
• Boiling Point: °Cat760mmHg
• PKA: 9.39±0.10(Predicted)
• Flash Point: °C
• PSA: 93.55000
• Density: 1.3g/cm³
• LogP: 3.19370
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• Exact Mass: 470.18417193
• Heavy Atom Count: 35
• Complexity: 722

Purity/Quality:

97% ^*data from raw suppliers

5'-O-Trityl-2'-deoxyuridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)O
• Isomeric SMILES: C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)O

Technology Process of 5'-O-Trityl-2'-deoxyuridine

There total 5 articles about 5'-O-Trityl-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2'-deoxyuridine (951-78-0,63844-76-8) + mono-4-methoxytrityl chloride (14470-28-1) → O5'-trityl-2'-deoxy-uridine (14270-73-6)

Guidance literature:

With pyridine; for 2h; Heating / reflux;

Reference yield: 97.0%

2'-deoxyuridine (951-78-0,63844-76-8) + trityl chloride (76-83-5) → O5'-trityl-2'-deoxy-uridine (14270-73-6)

Guidance literature:

With pyridine; at 50 ℃;

DOI:10.1021/jm050111e

Reference yield: 38.0%

2'-deoxyuridine (951-78-0,63844-76-8) + trityl chloride (76-83-5) → 2'-deoxy-3',5'-bis-O-triphenylmethyluridine (1140622-58-7) + O5'-trityl-2'-deoxy-uridine (14270-73-6)

Guidance literature:

In pyridine; at 80 ℃;

DOI:10.1016/j.ejmech.2013.04.034

upstream raw materials:

2'-deoxyuridine

trityl chloride

mono-4-methoxytrityl chloride

Downstream raw materials:

N³,3'-di-O-nicotinoyl-5'-O-trityl-2'-deoxyuridine

5-bromo-5'-O-trityl-2'-deoxyuridine

3'-acetylamino-5'-O-trityl-2',3'-dideoxyuridine

3'-amino-5'-O-trityl-2',3'-dideoxyuridine